过去一年中添加的文章，按日期排序

A novel anti-CD47 protein antibody and toll-like receptor agonist complex detects tumor surface CD-47 changes in early stage lung cancer by in vivo imaging

Y Xu, L Gu, L Zhu, Y Miao, X Cui - International Journal of Biological …, 2024 - Elsevier
2 天前 - … The macrophage-mediated uptake of ICG-R848@MOFs contributes to their
accumulation within the tumor microenvironment, facilitating targeted therapy. Furthermore, the …
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… MICROENVIRONMENT PROFILING OF BRAF-FUSION PILOCYTIC ASTROCYTOMA: DIRECTIONAL PRIORITIZATION OF IMMUNOTHERAPEUTIC TARGETS

S Tripathi, H Najem, A Heimberger… - Neuro-Oncology, 2024 - ncbi.nlm.nih.gov
2 天前 - … The tumor microenvironment of BRAF-fusion PA was notable for antigen presentation
… Our results are consistent with others that suggest potential benefit in targeting tumors …
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MDB-89. DETERMINING THE IMMUNOMODULATORY POTENTIAL OF PI3KΓ IN AGGRESSIVE MEDULLOBLASTOMA AND THE TUMOR MICROENVIRONMENT

RM Yazejian, K Moziak, NM Perez, J Pensabene… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … embryonal brain tumor arising in the cerebellum. It has a “cold” tumor
microenvironment (TME) characterized by an abundance of immunosuppressive Tumor Associated …
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IMMU-22. B7-H3 NANOBODY CAR-T AND SOLUBLE TREM2 GENETICALLY ENGINEERED MYELOID CELL THERAPY IN MURINE SYNGENEIC GLIOBLASTOMA

JC Cronk, R El Meskini, M Fanuzzi, D Atkinson… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … a major impediment to CAR-T cell therapy for CNS tumors. Importantly, CAR-T
cells are … the tumor immune response or tumor microenvironment. CNS tumor macrophages …
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EPEN-09. TARGETING EPHB2/ABL1 RESTORES ANTI-TUMOR IMMUNITY IN A PRECLINICAL MODEL OF EPENDYMOMA

J Ren, Z Amoozgar, TP Uccello, Y Zhao, P Lei… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … In conclusion, these data indicate that Dasatinib may be an effective therapy for
EPHB2-driven molecular subgroup of EPN by activating the anti-tumor immune response and …
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DIPG-86. INVESTIGATING THE TUMOR ENVIRONMENT AND SIGNALING DEPENDENCIES DRIVING DIFFUSE MIDLINE GLIOMA TUMOR INITIATION …

P Patel, S Ryall, B Kukreja, A Turinski… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … 1) Inadequate multiomics studies hindering our understanding of DMG evolution
and tumor progression, and 2) Limited comprehension of the tumor microenvironment in DMG. …
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ETMR-25. UNRAVELING THE ROLE OF SHH SIGNALING PATHWAY IN RETINOBLASTOMA

X Liu, J Zhang, Z Xu, A Dlugosz, S Frank, P Meyer… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … , we identified the crucial role of the Shh signaling pathway in Rb1 mutation-induced
tumorigenesis, highlighting its potential as a novel therapeutic target for RB treatment. …
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IMMU-06. CAR DESIGN SHAPES THE BRAIN TUMOR IMMUNE MICROENVIRONMENT: IMPACT ON ACTIVITY AND PERSISTENCE OF ANTI-GLIOMA ADOPTIVE T …

D Haydar, J Ibañez-Vega, J Crawford, Z Yi… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … The limited efficacy is partly attributed to the immunosuppressive tumor
microenvironment (TME), a characteristic not fully recapitulated in investigations using xenograft …
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HGG-07. INVESTIGATING THE ROLE OF SENESCENCE IN PEDIATRIC HIGH-GRADE GLIOMAS

TH Chang, A Nassar, C Kleinman… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … tumor microenvironment (TME). … tumors with dismal outcomes and limited therapeutic
options. Accumulating evidence suggests potential therapeutic vulnerabilities in targeting …
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DIPG-17. DYSREGULATED PURINE METABOLISM IN A LETHAL CHILDHOOD BRAINSTEM TUMOR REVEALS NEW TREATMENT STRATEGIES WITH OLD …

I Mersich, S Congrove, M Horchar, R Caceres… - Neuro …, 2024 - ncbi.nlm.nih.gov
2 天前 - … the microenvironment sensitized DIPGs to the antifolate methotrexate. Our studies
identify ATIC as a novel target … strategy with antifolates in children with this lethal brain tumor. …
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