… Thus, exosomal PD-L1 represents a novel therapeutic target that could bypass resistance to
… potential therapeutic targets in immune microenvironments, thus ICIs that target the PD-1/PD…

… therapy, also including the latest results of clinical studies discussed at recent oncological
meetings. Finally, promising new therapeutic targets … progression as therapeutic targets or …

… oxygen, generate oxygen, or target tumor hypoxia. The tumor microenvironment (TME) has
… TME has emerged as a strategy to facilitate cancer therapy. Recently, great progress in TME …

… In addition to molecule targets, the products of some metabolic processes can also serve as
therapeutic targets. For example, phosphoenolpyruvate (PEP) is an intermediate metabolite …

… In conclusion, we have described the tumor microenvironment to better understand the …
or active targeted drug delivery systems. Nanocarriers can escape from tumor vasculature …

… tumor microenvironment and discuss the potential clinical implications. As the microenvironment
… various components in the microenvironment in tumor progression, invasiveness, and …

… These alterations are associated with a tumor microenvironment (… microenvironment.
Ongoing efforts to influence the TME by targeting mutant RAS and thereby sensitizing these tumors …

… Besides the active resistance driven by genetic and epigenetic alterations in tumor cells,
the tumor microenvironment (TME) has also been reported to be a crucial regulator in …

… emergence of the M2-polarized phenotype and retarded tumor progression in 4T1/BALB/c-…
, implying that therapies targeting these cytokines are optimal for tumors that are refractory …

… therapies, several of which are reviewed here. Particular emphasis is placed on targeting
such components of the TME as tumor… (CAFs) overexpressing specific therapy targets such as …