Translational horizons in the tumor microenvironment: harnessing breakthroughs and targeting cures

Y Sun - Medicinal research reviews, 2015 - Wiley Online Library
… Further, treatment itself activates the microenvironment by … which the tumor microenvironment
drives development of … networks of the tumor microenvironment in pathological settings will …

New horizons in tumor microenvironment biology: challenges and opportunities

F Chen, X Zhuang, L Lin, P Yu, Y Wang, Y Shi, G Hu… - BMC medicine, 2015 - Springer
… to clinical conditions would significantly accelerate the advancement of translational medicine.
Second, the TME-stimulated cancer resistance and disease resilience may be technically …

[HTML][HTML] Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside

R Bhome, HA Al Saihati, RW Goh, MD Bullock… - … horizons in translational …, 2016 - Elsevier
… The concept of activating or inhibiting other cell types within the tumour microenvironment
is … This review outlines key players in the stromal tumour microenvironment and discusses …

[PDF][PDF] Horizons in Translational Medicine

R Bhome, HA Al-Saihati, RW Goh, JN Bullock… - 2016 - researchgate.net
… The concept of activating or inhibiting other cell types within the tumour microenvironment
is relatively novel and has the advantage of targeting cells which are genetically stable and …

Current and future horizons of patient-derived xenograft models in colorectal cancer translational research

A Inoue, AK Deem, S Kopetz, TP Heffernan, GF Draetta… - Cancers, 2019 - mdpi.com
… the primary tumor, having lost, or been enriched for specific subclones, in addition to missing
relevant components of the human tumor microenvironment [7]. As a result, the US National …

[PDF][PDF] New Horizons in Translational Medicine

R Bhome, HA Al Saihati, RW Goh, MD Bullock… - 2016 - academia.edu
… The concept of activating or inhibiting other cell types within the tumour microenvironment
is … This review outlines key players in the stromal tumour microenvironment and discusses …

Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments

AS Fattahi, M Jafari, G Farahavar, SS Abolmaali… - Critical Reviews in …, 2024 - Elsevier
… aim to target tumor cells. However, tumor microenvironment (TME), which comprises a
complex network of various cells and molecular cues guiding tumor growth and progression, …

Tumor microenvironment as a complex milieu driving cancer progression: a mini review

Z Li, J Li, X Bai, X Huang, Q Wang - Clinical and Translational Oncology, 2024 - Springer
… It has been spotlighted that the Tumor Microenvironment (TME) is crucial for comprehending
cancer progression and therapeutic resistance. Therefore, this comprehensive review …

[HTML][HTML] … in overcoming therapeutic resistance in castration-resistant prostate cancer: targeting the androgen receptor-regulated tumor immune microenvironment

B Cheng, H Huang - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
… Recent studies have highlighted the effects of AR signaling on immune cell function and
immune-mediated anti-tumor responses within the tumor microenvironment 2,3 . Androgens …

Role of the tumor microenvironment in cancer hallmarks and targeted therapy

R Naser, I Fakhoury, A El-Fouani… - International …, 2022 - spandidos-publications.com
tumors. These cellular and non‑cellular stromal components form the tumor microenvironment
(TME), which co‑evolves with tumortranslational medicine (311). The cross-talk among …