The Tat protein of HIV-1 induces tumor necrosis factor-α production: implications for HIV-1-associated neurological diseases

P Chen, M Mayne, C Power, A Nath - Journal of Biological Chemistry, 1997 - ASBMB
HIV-mediated dementia is clinically and … of tumor necrosis factor (TNF)-α, both of which
occur in an environment of small numbers of infected cells. We examined the possibility that HIV

Tumor necrosis factor α inhibits glutamate uptake by primary human astrocytes: implications for pathogenesis of HIV-1 dementia

SM Fine, RA Angel, SW Perry, LG Epstein… - Journal of Biological …, 1996 - ASBMB
… Human immunodeficiency virus (HIV) infection is commonly … extensive infection of brain cells
by HIV, suggesting that indirect … cytokine, tumor necrosis factor α (TNFα), produced by HIV-1-…

Tumor necrosis Factor-α/Caehectin enhances human immunodeficiency virus type 1 replication in primary macrophages

JW Mellors, BP Griffith, MA Ortiz… - Journal of Infectious …, 1991 - academic.oup.com
… are important target cells for human immunodeficiency virus type 1 (HIV-l). The ability … tumor
necrosis factoro:/cachectin (TNFo:), a cytokine with macrophage-activating properties, on HIV

Elevated alpha–tumor necrosis factor levels in spinal fluid from HIV1–infected patients with central nervous system involvement

LME Grimaldi, GV Martino… - Annals of Neurology …, 1991 - Wiley Online Library
… To assess the role of alpha-tumor necrosis factor in the pathogenesis of … human
immunodeficiency virus type 1 infection, we recorded clinical data and measured alpha-tumor

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

SG Wilt, E Milward, JM Zhou… - Annals of Neurology …, 1995 - Wiley Online Library
tumor necrosis factor (TNF)-a message have been observed in the brains of some human
immunodeficiency virus type 1 (HIV-1… role of TNF-a in HIV-1 encephalopathy. Human microglia …

HIV-1 Tat induces neuronal death via tumor necrosis factor-α and activation of non-N-methyl-D-aspartate receptors by a NFκB-independent mechanism

DR New, SB Maggirwar, LG Epstein, S Dewhurst… - Journal of Biological …, 1998 - ASBMB
Human immunodeficiency virus type 1 (HIV-1) infection of the … be multifactorial and indirect,
since HIV-1 productively infects brain-… HIV-1 infection of macrophages and microglia leads to …

In situ detection of PCR-amplified HIV-1 nucleic acids and tumor necrosis factor cDNA in cervical tissues.

GJ Nuovo, A Forde, P MacConnell… - The American journal of …, 1993 - ncbi.nlm.nih.gov
… The specificity of the in situ DNA and cDNA product was checked in the HIV-1-… HIV-1 DNA
in either the HIV1-infected or sham-infected cells.A signal was evident, however, in the HIV-1-…

In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system.

GJ Nuovo, F Gallery, P MacConnell… - The American journal of …, 1994 - ncbi.nlm.nih.gov
… EO: Persistent human immunodeficiency virus type 1 infection in human fetal glial cells
reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor a and interleukin-1 j3. J …

Tumor necrosis factor-α in pediatric HIV-1 infection

M Ellaurie, A Rubinstein - AiDS, 1992 - journals.lww.com
… prognostic value of serum tumor necrosis factor-o. (TNF-o) levels in HIV-1-infected children.
Design: Serum levels of INF-a were evaluated in 57 HIV-1-infected symptomatic children …

Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor

JE Merrill, Y Koyanagi, IS Chen - Journal of virology, 1989 - Am Soc Microbiol
… interleukin-1 (IL-1) and tumor necrosis factor alpha (… human immunodeficiency virus type
1 (HIV-1) virions induce normal peripheral blood mononuclear phagocytes to produce both IL-1