Tumor mutational burden as a predictive biomarker in solid tumors
… TMB variability across solid tumors with implications for cutoff selection, its association with
benefit from ICIs, and strategies to optimize TMB as a predictive biomarker for ICIs in clinical …
benefit from ICIs, and strategies to optimize TMB as a predictive biomarker for ICIs in clinical …
Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
… biomarker was independent of other putative biomarkers, we compared ctDNA B and ∆ctDNA
C3 with tumor … Only two of 94 patients had microsatellite instability high (MSI-H) tumors (…
C3 with tumor … Only two of 94 patients had microsatellite instability high (MSI-H) tumors (…
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients
A Kirilovsky, F Marliot, C El Sissy… - International …, 2016 - academic.oup.com
… tumor and phenotype activation status) could become a central biomarker that is predictive
for … of the prognostic and predictive roles of the immune infiltrate in cancer patients and (ii) the …
for … of the prognostic and predictive roles of the immune infiltrate in cancer patients and (ii) the …
PD-L1 expression as a predictive biomarker in cancer immunotherapy
SP Patel, R Kurzrock - Molecular cancer therapeutics, 2015 - AACR
… responses in some patients with low levels … predictive biomarker. An improved understanding
of the host immune system and tumor microenvironment will better elucidate which patients …
of the host immune system and tumor microenvironment will better elucidate which patients …
Tumor mutational burden as a predictive biomarker for response to immune checkpoint inhibitors: a review of current evidence
SJ Klempner, D Fabrizio, S Bane, M Reinhart… - The …, 2020 - academic.oup.com
… paradigms across multiple tumor types. However, only a subset of patients treated with …
requires additional predictive biomarkers that further establish which patients are most likely …
requires additional predictive biomarkers that further establish which patients are most likely …
Circulating tumor cells as a predictive biomarker in patients with hormone-sensitive prostate cancer
OB Goodman Jr, JT Symanowski, A Loudyi… - Clinical genitourinary …, 2011 - Elsevier
… in patients receiving prior … patients with hormone-sensitive prostate cancer, undergoing
therapy for HSPC at our institution. A univariate analysis of potential predictive biomarkers …
therapy for HSPC at our institution. A univariate analysis of potential predictive biomarkers …
Predictive biomarkers: a paradigm shift towards personalized cancer medicine
NB La Thangue, DJ Kerr - Nature reviews Clinical oncology, 2011 - nature.com
… proliferation and apoptosis in the tumor upon delivery of a drug, … , predictive biomarkers
assess the likelihood that the tumor … There are a small number of predictive biomarkers that have …
assess the likelihood that the tumor … There are a small number of predictive biomarkers that have …
[HTML][HTML] Tumor mutational burden assessment as a predictive biomarker for immunotherapy in lung cancer patients: getting ready for prime-time or not?
S Heeke, P Hofman - Translational lung cancer research, 2018 - ncbi.nlm.nih.gov
… L1 IHC biomarker. PD-L1 IHC and TMB are currently the two best predictive biomarkers that
… treatment decisions in advanced or metastatic NSCLC patients. The aim of this review is to …
… treatment decisions in advanced or metastatic NSCLC patients. The aim of this review is to …
[HTML][HTML] Prognostic and predictive biomarkers: tools in personalized oncology
E Nalejska, E Mączyńska… - Molecular diagnosis & …, 2014 - Springer
… may become both a prognostic and a predictive biomarker. An analysis of over 600 miRNAs
from tumor tissues derived from patients with bladder cancer treated with cisplatin allowed …
from tumor tissues derived from patients with bladder cancer treated with cisplatin allowed …
[HTML][HTML] The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer
M Takahashi, M Cuatrecasas, F Balaguer, K Hur… - 2012 - journals.plos.org
… Mutations in KRAS are the only established predictive markers for selecting treatment
strategies in CRC. Patients with tumors harboring mutations in codon 12 or 13 of the KRAS gene …
strategies in CRC. Patients with tumors harboring mutations in codon 12 or 13 of the KRAS gene …
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