… of the mechanisms behind sensitization of tumors to PARP … mechanisms of action of
PARPi, biomarkers of the tumor … combination therapies and mechanisms of tumor resistance. …

… all of the above-mentioned resistance mechanisms. However, after more … resistance
mechanism to cisplatin might be related with hyperactivation of telomerase and inability of the tumor …

… in drug resistance, and their targets in different tumor cells. … in drug-resistant tumor cells, we
will analyze the mechanisms of … mechanisms of miRNAs in regulating tumor drug resistance. …

… This chapter presents an overview of the drug resistance mechanisms. … of human tumors.
Therapeutic approaches aimed to overcome a single resistance mechanism have been …

… This review describes mechanisms by which Herceptin inhibits cell growth in breast cancers
… resistance within 1 year [48], [62]. Elucidating the molecular mechanisms by which tumors …

… by many other causes besides tumor cell alterations; it may be … this paper only the mechanisms
of drug resistance of cells will … diversity of the mechanisms of cellular resistance to drugs. …

… CDDP has clinical benefit for several types of solid tumors; however, the efficiency of
CDDP is often accompanied by toxic side effects and tumor resistance, which in turn leads to …

… provides insights into the basis of irinotecan toxicity and tumor resistance [10]. Irinotecan is a
unique … The metabolism and mechanism of action of irinotecan are summarized in Figure 1. …

… resistant tumors in patients treated with tubulin-binding agents. Clinical trials aiming to
sensitize MDR-positive tumors … the possible nonMDR mechanisms of resistance to tubulin-binding …

… It has several mechanisms of action consisting of the anti-tumor effects of trastuzumab
and those of DM1, a cytotoxic anti-microtubule agent released within the target cells upon …