… secrete growth factors, cytokines and extracellular matrix proteins which promote growth, …
Fibroblasts are the predominant constituent of the tumor stroma and Hepatocyte Growth Factor (…

… There are numerous applications for monoclonal antibody therapy in the treatment of … the
effects of growth factor receptors. Treatment targeted to the growth factor receptors has shown …

… growth factor (IGF) signaling pathway is implicated in cellular mitogenesis, angiogenesis,
tumor … Inhibition of this pathway results in decreased cell growth, inhibition of tumor formation in …

… This allows the proliferating cells to migrate toward the source of the growth factor stimulus
(ie, the tumor), a process that is dependent on the complex interactions of cellular adhesion …

… As with nonmalignant cells, tumor growth and … epidermal growth factor receptor (EGFR),
which has been shown to play an important role in the growth and survival of many solid tumors. …

… of our findings for antiangiogenic therapy. Agents designed to specifically block one vascular
growth factor from binding to its receptor may not be effective, unless that factor is the most …

… role in tumor angiogenesis, vascular endothelial growth factor is considered as a key
target in therapeutic approaches. This article aims to review the critical role of VEGF in tumor …

… Tumor cells can tilt the balance toward stimulatory angiogenic factors to drive vascular growth
by releasing growth factors, … In addition, tumors may elicit an inflammatory response that …

… to inhibit neovascularization and tumor growth. For example… factors such as vascular
endothelial growth factor/vascular permeability factor (VEGF/VPF) inhibits new blood vessel growth …

… growth factors from liver endothelial cells (19). Importantly, VEGFR-1 signaling has been
implicated in tumor … clusters at tumor-specific premetastatic sites before the arrival of tumor cells …