… Growth of solid tumors depends on angiogenesis, the process by which new blood vessels
… Dual regulation of vascular endothelial growth factor availability by genetic and proteolytic …

… by transforming growth factor-β (… tumor growth have been shown to exert suppressive effects
on the immune system. Among such factors the most prominent is transforming growth factor…

… Placenta growth factor (PlGF) and VEGFB bind selectively to VEGF receptor 1 (VEGFR1), …
certain growth factors such as hepatocyte growth factor and connective tissue growth factor, …

Purpose Prognosis is poor for Ewing sarcoma patients with metastasis at diagnosis. We
intensified a five-drug therapy (ifosfamide, etoposide alternated with vincristine, doxorubicin, …

… growth factor receptor and, at higher concentrations, the vascular endothelial growth factor
… We hypothesized that combined inhibition of upstream epidermal growth factor receptor and …

… Last, TAMs secrete factors that promote angiogenesis, including vascular endothelial
growth factor, a protein that further supports the growth and spread of tumors. Thus, TAMs can …

… This would indicate that other growth factor receptors are dependent on a functional IGF-I
auto … Since the IGF-IR is expressed in many cell types and IGF-I is a growth factor for a great …

… Whereas VEGF-A has been shown to play an important role in angiogenesis and has
emerged as an attractive target for antiangiogenic tumor therapy, the vascular effects of other …

… The hypoxic tumor microenvironment is a stimulus for angiogenesis, up-regulating expression
of angiogenic factors such as vascular endothelial growth factor (VEGF) by tumor (5) and …

… growth factor (VEGF) is an angiogenic growth factor that is a primary stimulant of the
vascularization of solid tumors. … in the tumor cells and by hypoxic conditions inside the tumor mass. …