Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment

BR Achyut, L Yang - Gastroenterology, 2011 - Elsevier
… create an environment that promotes tumor progression by providing growth factors, pro-angiogenic
factors, proteases, and adhesion molecules that facilitate tumor cell proliferation, …

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant hemotherapy

XD Yang, XC Jia, JRF Corvalan, P Wang, CG Davis… - Cancer research, 1999 - AACR
… the involvement of an autocrine growth control in the progression of these tumors (2, 3, …
growth factors and EGFr could result in the arrest of tumor growth and could possibly affect tumor

Review of epidermal growth factor receptor biology

RS Herbst - International Journal of Radiation Oncology* Biology …, 2004 - Elsevier
… , such targeted therapies may exert cytostatic or cytotoxic effects on tumors. Growth factor
receptors comprise one such class of targets, and therapies directed against these cell surface …

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors

M Prewett, J Huber, Y Li, A Santiago, W O'Connor… - Cancer research, 1999 - AACR
tumor growth. Angiogenesis in vivo was examined using a growth factor supplemented (basic
fibroblast growth factor + VEGF) Matrigel plug and an alginate-encapsulated tumor cell (…

… transforming growth factor β in tumor progression: Molecular mechanisms of immune privilege via Fas‐mediated apoptosis and potential targets for cancer therapy

R Kim, M Emi, K Tanabe, Y Uchida… - … International Journal of …, 2004 - Wiley Online Library
… cells that can escape immune surveillance and facilitate tumor progression and
metastasis. Transforming growth factor β (TGF-β) is a potent growth inhibitor and has tumor-suppressing …

Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis

R Giavazzi, B Sennino, D Coltrini, A Garofalo… - The American journal of …, 2003 - Elsevier
Tumors express more than a single angiogenic growth factor. To investigate the relative …
growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) on tumor growth and …

Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes

JA McCart, JM Ward, J Lee, Y Hu, HR Alexander… - Cancer research, 2001 - AACR
tumor specificity of this vector, we have developed a combined thymidine kinase-deleted (TK−)
and vaccinia growth factor… vaccinia virus, tissues and tumor were harvested for viral titer …

Interactions between estrogen and growth factor receptors in human breast cancers and the tumor‐associated vasculature

RJ Pietras - The breast journal, 2003 - Wiley Online Library
… and growth factor signaling pathways regulate the secretion of vascular endothelial growth
factors that stimulate tumor-… significantly impact breast cancer cell growth and survival, and …

Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor

C Xia, Q Meng, LZ Liu, Y Rojanasakul, XR Wang… - Cancer research, 2007 - AACR
… -inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) … tumor growth.
NOX4 knockdown in ovarian cancer cells decreased the levels of VEGF and HIF-1α and tumor

Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family

S Dalal, AM Berry, CJ Cullinane, DC Mangham… - Clinical Cancer …, 2005 - AACR
… profile of the angiogenic growth factors VEGF, PlGF, bFGF, … VEGF as the single angiogenic
growth factor most frequently … pathway in an ESFT sc growth mouse model. Two different …