… Among them, VEGFR2 has been identified as a promising tumor therapy target [41… tumor
endothelial cells is closely linked to the occurrence and development of multiple types of tumors …

… inhibitors such as sunitinib and sorafenib are also effective in antiangiogenic tumor therapy
by inhibiting VEGFR signaling. Anti-VEGF drugs are a promising therapy for cancer patients. …

… of radiation markedly enhanced the therapeutic efficacy in all … ) tumors growing sc on BALB/c
nu/nu mice. This study shows that radiation is an integral component of local tumor therapy …

… of malignant tumors. Nowadays… receptor tyrosine kinase inhibitors (TKIs). The development
of TKIs targeting pro-angiogenic receptors, mainly vascular endothelial growth factor receptor …

… of inhibiting tumor neoangiogenesis or normalizing the tumor vasculature. Among the most
promising therapeutic targets are receptor … prospects of RTK inhibition in anti-tumor therapy. …

… induced a reduction of tumor growth in vivo [39,40]. Although several of these … therapeutic
agents, we will focus on VEGF neutralizing antibodies and VEGFR tyrosine-kinase inhibitors …

… cells, ie negative costimulatory receptors such as CTLA4 and PD1 … inhibitors” or antibodies
to negative costimulatory receptors led to therapeutic strategies to generate higher anti-tumor …

… 120 of them were classified as therapeutic drugs for solid tumors according to their initial …
or combined therapy. However, the available targets are still mainly limited to receptor tyrosine …

… Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits
tumor growth, metastasis, and mortality rate. Proc Natl Acad Sci USA 1998; 95: 8795-800. [45…

… receptors appears to be critical for the growth of many tumors. … The concentration of mAb
needed for receptor inhibition in … inhibitors, and the specificity of the mAb for EGF receptors is …