… In this Perspective, we highlight recent key developments in the field, including signalling
and metabolic pathways that support tumour growth; the molecular basis of how …

… conditions in growing tumours. Finally, we will examine how deregulated lipid metabolism
in cancer cells might contribute to the complex interactions between cancer cells and the …

… that arises due to the metabolic plasticity of tumour cells, and novel metabolic targets must
be pursued to improve outcomes. In this Review, we discuss cancer metabolism, with a focus …

… cancer metabolism, in which ATP generation is not the sole metabolic requirement of tumour
… This turning point has led to the realization that the metabolic alterations present in cancer …

… Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as metabolite
availability in the tumour … and describe the influence of the TME on tumour cell metabolism. …

… Understanding the regulation of cellular metabolism is key for unravelling cancer metabolism
as an attractive target for therapeutic exploitation. In particular, we will focus on resistance …

… Below, we discuss the metabolic strategies employed by cancer cells to sustain proliferation,
as these networks are likely to be engaged even at the earliest stages of tumour formation. …

… dampen or promote tumour progression. In this Review, we cover the fundamentals of
cancer metabolism and focus on recent small-molecule drug discovery efforts to target cancer. …

… cancer metabolism is more complex than originally thought and that tumours display a rather
large collection of metabolic … central questions around the metabolism of tumour cells. For …

… , tumour cells face selection pressures that force them to continuously optimize dominant
metabolic pathways, and tumour cells thus undergo major metabolic reorganizations. In general…