FGF s: crucial factors that regulate tumour initiation and progression

Q Jing, Y Wang, H Liu, X Deng, L Jiang, R Liu… - Cell …, 2016 - Wiley Online Library
… , wound healing, tissue homoeostasis/regeneration and metabolism.1, 2 There are 23
FGF (FGF-1–23) ligands in mammals, which are capable of binding to fibroblast growth factor

Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis

H Endo, K Hosono, T Uchiyama, E Sakai, M Sugiyama… - Gut, 2011 - gut.bmj.com
… Conclusions Our findings indicate that leptin is important for CRC growth in obesity, and
acts as a growth factor for CRC at stages subsequent to tumour initiation in colorectal …

Growth factor signalling in prostatic growth: significance in tumour development and therapeutic targeting

AR Reynolds, N Kyprianou - British journal of pharmacology, 2006 - Wiley Online Library
… of the prosurvival characteristics of these growth factor pathways is still evolving, the impact
that growth factors such a epidermal growth factor and transforming growth factor-β can be …

VEGF targets the tumour cell

HL Goel, AM Mercurio - Nature Reviews Cancer, 2013 - nature.com
… cells, primarily because of their ability to regulate the function and the trafficking of growth
factor receptors and integrins. This has important implications for our understanding of …

Fibroblast growth factor signalling: from development to cancer

N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
… This partly reflects the increased release of FGFs: as tumours invade and degrade the
extracellular matrix FGF is liberated 4 , freeing it to function as a paracrine growth factor. Tumour

Significance of angiogenesis in tumour progression and metastasis

A Bikfalvi - European Journal of Cancer, 1995 - Elsevier
… are molecules from the fibroblast growth factor (FGF) and the transforming growth factor-p
(TGF… growth factor (VEGF) and angiostatin. The nature of the tumour angiogenesis factor is not …

[HTML][HTML] Tumour initiation: a discussion on evidence for a “load-trigger” mechanism

JJ Evans, MM Alkaisi, PH Sykes - Cell Biochemistry and Biophysics, 2019 - Springer
… An example of modulation of cell behaviour by altering the environment but without growth
factor addition or gene modification is the observation [42] that the phenotype expressed by …

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

KJ Kim, B Li, J Winer, M Armanini, N Gillett, HS Phillips… - Nature, 1993 - nature.com
… There are several potential mediators of tumour angiogenesis, including basic and acidic
fibroblast growth factors, tumour necrosis factor-a and transforming factors-a and -('*. But it is …

Stimulation of tumour growth by wound-derived growth factors

R Abramovitch, M Marikovsky, G Meir… - British journal of …, 1999 - nature.com
… the stimulatory effects of injuries on tumour progression can be attributed to a … key growth
factors that are found in healing wounds and exert a major stimulatory effect on tumour growth. …

Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour …

JP Crew, S Fuggle, R Bicknell, DW Cranston… - British journal of …, 2000 - nature.com
… Summary Vascular endothelial growth factor (VEGF) is an important factor mediating tumour
tumours (stage pTa and pT1) contrasting with low expression in muscle invasive tumours (…