Patient-derived tumour organoids: a bridge between cancer biology and personalised therapy

W Wu, X Li, S Yu - Acta Biomaterialia, 2022 - Elsevier
tumour organoids (PDOs) have revolutionised our understanding of cancer biology and
the applications of personalised therapies… characteristics of parental tumours. Given these …

[HTML][HTML] Current concepts in tumour-derived organoids

RJ Porter, GI Murray, MH McLean - British journal of cancer, 2020 - nature.com
… for studying cancer and directing personalised therapies. This review aims to highlight how
… Our ability to manipulate tumour organoids further improves the utility of this culture system in …

[HTML][HTML] The efficacy of using patient-derived organoids to predict treatment response in Colorectal Cancer

C Su, KA Olsen, CE Bond, VLJ Whitehall - Cancers, 2023 - mdpi.com
Tumour organoids are promising models for personalised medicine in the context of …
Reporting in vitro response of patient-derived tumour organoids to therapeutic agents in a way that …

Personalised radiation therapy taking both the tumour and patient into consideration

J Overgaard, MC Aznar, C Bacchus… - Radiotherapy and …, 2022 - thegreenjournal.com
… normal and tumour organoids (PDO) and used to assess radiation responses. Such organoid
… allow assessment of personalised therapeutic ratio and prediction of treatment response [ …

[HTML][HTML] A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids

DKH Thng, L Hooi, BE Siew, KY Lee, IJW Tan… - NPJ Precision …, 2024 - nature.com
therapies to circumvent the frequent emergence of tumourpersonalised oncology (FPO)
approach in identifying tumour vulnerabilities by observing the phenotypic changes in tumour

[HTML][HTML] Head and neck cancer patient-derived tumouroid cultures: Opportunities and challenges

BWMTJ Basnayake, P Leo, S Rao, S Vasani… - British Journal of …, 2023 - nature.com
… cancer organoids/tumouroids can more faithfully mimic the tumour in … highly personalised
in vitro model that replicates the tumour … , and responsiveness to therapy in vivo, essentially …

[HTML][HTML] Patient-derived xenograft and organoid models for precision medicine targeting of the tumour microenvironment in head and neck cancer

TW Lee, A Lai, JK Harms, DC Singleton, BD Dickson… - Cancers, 2020 - mdpi.com
… -derived xenograft and organoid models of … to therapy of the human tumours they originated
from. In this review, we discuss the development of patient-derived xenograft and organoid

Precision oncology using ex vivo technology: a step towards individualised cancer care?

ST Williams, G Wells, S Conroy, H Gagg… - Expert Reviews in …, 2022 - cambridge.org
… However, these techniques also have a high potential to offer personalised therapies to …
between parental tumours and corresponding organoid (Ref. 60). However, organoids can also …

[HTML][HTML] … system combining comprehensive genotyping and organoid cultures for identifying and testing genotype-oriented personalised medicine for pancreatobiliary …

M Shiihara, T Ishikawa, Y Saiki, Y Omori… - European Journal of …, 2021 - Elsevier
… To identify potential targeted therapeutic molecules in the patients' primary tumours, we
performed WES of six biliary tumours from which cancer organoids were obtained. We selected …

Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy

D Chen, L Xu, M Xuan, Q Chu… - Clinical and Translational …, 2024 - Wiley Online Library
… tissue and tumour-derived organoids allow the screening of therapeutic agents … tumour-reactive
lymphocytes in a personalised manner. Their work revealed that tumour organoids