… In the ensuing twenty years since Shc was first identified, … phosphorylation upon engagement
of the adaptor with an RTK, … downstream transduction components, Shc proteins provide a …

… The Shc (Src homology and collagen) family of adaptor molecules plays an important role
in mediating signaling events that link activated cell surface proteins such as receptor tyrosine …

… (Shc) proteins have been considered archetypal adaptors of … This response is not elicited
by other Shc proteins and … and EGFR that is unprecedented among signaling adaptors. …

… Despite their conserved structure and common binding partners, the Shc adaptors and
their isoforms can give rise to distinct downstream signals and make unique physiological …

… Shc showed that although FERM domain of Jak3 was sufficient for binding to Shc, CH1 and
PID domains of Shc … truncation of Shc had an effect on the interactions between Shc and P-…

… The specific components of the cascade vary greatly among different stimuli, but the
architecture of the pathway usually includes a set of adaptor molecules (ShC, GRb 2 , PLCgamma, …

Rai (Shc C or N-Shc) is a neuron-specific member of the family of Shc-like adaptor proteins.
Rai functions in the cytoplasmic propagation of Ret-dependent survival signals and regulates…

Pancreatic ductal adenocarcinomas are highly malignant cancers characterized by extensive
invasion into surrounding tissues, metastasis to distant organs, and a limited response to …

… shown a 5-year failure-free survival of 60% versus 36% and a 5-year overall survival of 70%
… for patients older than 40 years. Compared to the 5-year overall survival associated with …

… The Shc locus encodes three adaptor proteins (p46 Shc , p52 Shc , and p66 Shc ) that are
… There is evidence that p66 Shc participates in pathways that influence oxidative stress and …