Immune profiling of thyroid carcinomas suggests the existence of two major phenotypes: an ATC-like and a PDTC-like

R Giannini, S Moretti, C Ugolini… - The Journal of …, 2019 - academic.oup.com
… These data indicated the existence of two major immune phenotypes in thyroid carcinoma:
an ATC-like one, including hot and altered–immunosuppressed tumors and a PDTC-like one, …

[HTML][HTML] Deep phenotyping reveals distinct immune signatures correlating with prognostication, treatment responses, and MRD status in multiple myeloma

K Papadimitriou, N Tsakirakis, P Malandrakis, P Vitsos… - Cancers, 2020 - mdpi.com
… In the present study, we applied deep phenotype analysis to characterize the immune
profile of peripheral blood (PB) and BM cells at different disease stages, and correlated PB and …

[HTML][HTML] Spatial and phenotypic immune profiling of metastatic colon cancer

J Lazarus, T Maj, JJ Smith, MP Lanfranca, A Rao… - JCI insight, 2018 - ncbi.nlm.nih.gov
… and adaptive immune system influence … 2, 10). Inversely, characteristics of the tumor cells
themselves play a significant role in shaping the phenotype and behavior of infiltrating immune

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

D Mathew, JR Giles, AE Baxter, DA Oldridge… - Science, 2020 - science.org
… features with extensive clinical data, disease severity scores, and temporal changes, we
built an integrated computational model that connected patient immune response phenotype to …

Phenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinoma

C Pan, Y Wang, Q Liu, Y Hu, J Fu, X Xie… - …, 2021 - Taylor & Francis
… the immune infiltrates in ESCC. The prognostic implication of certain immune phenotypes
in … immune cells highlight the complicated immune contexture of ESCC TME. Among these …

[HTML][HTML] Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D Mathew, JR Giles, AE Baxter, AR Greenplate, JE Wu… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… computational model that connected patient immune response phenotype to disease
severity. Moreover, this UMAP embedding approach allowed us to connect these integrated …

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

S Goswami, T Walle, AE Cornish, S Basu… - Nature medicine, 2020 - nature.com
immune checkpoint expression patterns and demands a comprehensive comparison of TIL
phenotypes … To address this need, we applied mass cytometry (CyTOF) to profile immune cell …

Longitudinal immune profiling reveals unique myeloid and T-cell phenotypes associated with spontaneous immunoediting in a prostate tumor model

CR Ager, AZ Obradovic, JM Arriaga… - Cancer immunology …, 2021 - AACR
… In this study, we performed high parameter longitudinal immune profiling and cellular depletion
assays to define the cellular determinants of immunoediting in NPK-C1, a transplantable …

Comprehensive profiling of poor-risk paired primary and recurrent triple-negative breast cancers reveals immune phenotype shifts

KE Hutchinson, SE Yost, CW Chang, RM Johnson… - Clinical Cancer …, 2020 - AACR
Immune gene signature scoring The immune gene signatures (gene lists) profiled in this …
The composite score for the immune-activating genes (n = 7) from Denkert and colleagues (27) …

[HTML][HTML] Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

JK Khalsa, N Cheng, J Keegan, A Chaudry… - Nature …, 2020 - nature.com
… the influence of resection on immune response, by performing immune profiling of tumors by
… report similarities between patient and mouse models with respect to immune phenotypes. …