Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection

SD Lawn, ST Butera, TM Folks - Clinical microbiology reviews, 2001 - Am Soc Microbiol
… that immune activation in response to HIV-1 infection plays a … and local exogenous
immune-activating stimuli may further … Direct or indirect reduction of immune activation is therefore …

Association of functional impairment with inflammation and immune activation in HIV type 1infected adults receiving effective antiretroviral therapy

KM Erlandson, AA Allshouse… - … Journal of infectious …, 2013 - academic.oup.com
… chronic immune activation and … infection is associated with markers of immune
activation and inflammation. Because immunosenescence is associated with frailty in non–HIV-infected

Innate immune activation in primary HIV-1 infection

JJ Chang, M Altfeld - The Journal of infectious diseases, 2010 - academic.oup.com
… of the immune response during acute human immunodeficiency virus type 1 (HIV-1) infection
in … The adaptive immune responses do not appear until after HIV-1 infection is already well …

TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection

A Zganiacz, M Santosuosso, J Wang… - The Journal of …, 2004 - Am Soc Clin Investig
… evidence to suggest that TNF-α controls type 1 immune activation at least in part by suppressing
T … the level of type 1 immune activation by restricting the number and activation of T cells …

MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands

A Meier, G Alter, N Frahm, H Sidhu, B Li… - Journal of …, 2007 - Am Soc Microbiol
… Here we show that immune activation in HIV-1-infected individuals declines rapidly after
initiation of HAART and that immune activation is directly associated with the level of HIV-1

Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection

MTL Roos, JMA Lange, REY de Goede… - Journal of Infectious …, 1992 - academic.oup.com
… acute HIV-1 infection. Activated CD8+ T cells were only transiently elevated in individuals
with SI variants, suggesting that an impaired cellular anti-HIV-1 immune response plays a role …

Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression

W Cao, BD Jamieson, LE Hultin, PM Hultin… - AIDS research and …, 2009 - liebertpub.com
activation and effector function. To investigate the correlation between Tregs and immune
activation during untreated chronic HIV-1 infection… Twenty HIV-1-infected fast progressors (FP) …

Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature

PJ van de Berg, KM Heutinck, R Raabe… - … Journal of infectious …, 2010 - academic.oup.com
… a type 1 cytokine polarization of the immune response, CMV probably contributes to the
pathogenesis of chronic allograft rejection. The systemic immune activationimmune activation is …

Type 1/Type 2 immunity in infectious diseases

B Spellberg, JE Edwards Jr - Clinical Infectious Diseases, 2001 - academic.oup.com
… or anti-cytokine antibodies at the time of initial infection is able to reverse the type 1/type
2 polarity at the outset of the immune response, it has proved difficult to reverse type 1 or …

Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease

SK Choudhary, N Vrisekoop, CA Jansen… - Journal of …, 2007 - Am Soc Microbiol
… In summary, despite high viral loads, HIV-1 infection did not evoke high levels of immune
activation or proliferation in these LTA-HVL. Although few patients could be studied, these data …