The replication competence of human immunodeficiency virus type 1 genomes containing
mutations in the nef open reading frame was evaluated in continuous cell lines. Mutants that …

We examined whether human immunodeficiency virus type 1 (HIV-1) fitness was altered upon
the acquisition of a set or subset of five mutations (A62V, V75I, F77L, F116Y, and Q151M) …

… in vitro activities of 10 of these HIV-1 IN mutants (28); the in … in vitro activity, our HIV-1 N120G
mutant has only a slight reduction in infectious titer compared with wild-type virus, but HIV-1 …

… immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) virions,
thereby inactivating infectivity. The inactivated virus was not detectably infectious in vitro (up to 5 …

… types 1 (HIV-1) and 2 (HIV-2) in vitro. We determined its antiviral activity against a number of
laboratory strains of HIV-1 … Inhibition of thein vitro infectivity and cytopathic effect of human T-…

… CCP increased the binding of HIV-1 and recombinant gpl 20 to H9 cells and recombinant …
of HIV-1 infectivity by CCP is due to its capacity to increase the adherence of HIV-1 to target …

… virus type 1 (HIV-1) principal gpl20 type-specific neutralization determinant can abolish the
infectivity of HIV-1 in … Challenge inocula of the lHb virus isolate were mixed in vitro with either …

… To ensure that the separation procedure or in vitro culture conditions did not induce detectable
cell … An infectious virus stock of the NL4-3 clone of HIV-1 (1) was prepared by transfecting …

… with three diverse isolates of human immunodeficiencyvirus type 1 (HIV-1). Productive infection
was noted … The recovery of infectious HIV-1 was again determined by expression of HIV-…

The role of glutathione (GSH) in the in vitro infection and replication of human herpes simplex
virus type 1 (HSV-1) was investigated. Intracellular endogenous GSH levels dramatically …