… drug resistance. Finally, we present our views on the continuing battle against “drug resistance,”
… guidelines and strategies on how to minimize the development of drug-resistant tumors. …

… growth factor receptor and erbB-2, by a new class of tyrosine kinase inhibitor. … factor receptor
tyrosine kinase inhibitor. Biochem Pharmacol 54~877-887, 1997 … a tyrosine kinase inhibitor, …

… Griffin, JD, Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-…
sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood …

… Cytotoxic cancer drugs are usually of high acute toxicity, which have the disadvantages of
poor selectivity, strong side effects and easy to produce drug resistance [1]. In recent years, …

… drug resistance, which eventually arises in most, if not all treated patients. Mechanisms of
drug resistance … By identifying resistance mechanisms, it should be possible to develop ‘second…

… mechanisms of TKI resistance paying particular attention to drug resistance which allows
for … for therapy by kinase inhibitors. The advent of tyrosine kinase inhibitors has dramatically …

… EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large …
limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will …

… Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer …
years, tyrosine kinase inhibitors (TKIs) have been developed to inhibit specific kinases whose …

… tyrosine kinase inhibitors (TKIs) have been developed to interfere with the activity of deregulated
kinases… in development of a characteristic drug resistance phenotype in cancer patients. …

… Numerous protein tyrosine kinase inhibitors (TKIs) have … protein phosphorylation-mediated
cellular signaling pathways that control tumor cell growth by targeting various tyrosine kinases…