… for stimulation of tyrosine kinase activity and biological function(63,64). The role of the second
tyrosine isless clear. In Jak2, substitution of the second tyrosine with phenylalanine hadno …

… ences between kinases allow the design of compounds which inhibit only an acceptable few.
This review gives a general overview of protein tyrosine kinase structural biology, including …

… Protein tyrosine kinases were first discovered as the transforming proteins of a number of …
Their transforming capacity appears to derive from the unbridled tyrosine kinase activity of a …

… to BY-kinases and eukaryotic tyrosine kinases [18], a histidine-kinase-like protein
autophosphorylating on tyrosine (DivL from Caulobacter crescentus) and a kinase using a guanidino-…

… Over the past ten years, several growth factor receptors have been shown to be ligand-regulated
tyrosine kinases. Tyrosine kinase activity is essential for signal transmission, …

… Tyro‐3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs)
characterized by a conserved sequence within the kinase domain and adhesion molecule‐like …

… Receptor tyrosine kinases (RTKs) were believed until recently to act at the cell membrane in
… domain would activate the intrinsic tyrosine kinase activity in the intracellular domain), which …

… receptor phosphorylation by cellular kinases. The tyrosine kinase receptors are essential for
… Mutations that remove normal regulatory constraints on the ~ 290 amino acid kinase core of …

… view of the SYK tyrosine kinase. This Review summarizes our current understanding of the
diverse roles of SYK, in both immune and non-immune biological responses, and describes …

… Human Genome Project more than 90 tyrosine kinases have been found out. … of tyrosine
kinase in cellular signaling circuits that are implicated in cancer development. Tyrosine kinases …