Tyrosine kinases as targets for cancer therapy
A Levitzki - European journal of cancer, 2002 - Elsevier
… tyrosine kinases (PTKs). PTKs are positioned in key crossroads within the cellular communication
network and function as master switches. Their regulated signaling is pivotal to normal …
network and function as master switches. Their regulated signaling is pivotal to normal …
Protein tyrosine kinase inhibitors as novel therapeutic agents
A Levitzki - Pharmacology & therapeutics, 1999 - Elsevier
… Protein tyrosine kinases (PTKs) play a key role in normal cell … tyrosine phosphorylation
inhibitors (tyrphostins) as potential … , as well as at nonreceptor, tyrosine kinases. Some of these …
inhibitors (tyrphostins) as potential … , as well as at nonreceptor, tyrosine kinases. Some of these …
Therapeutic potential of inhibiting Bruton's tyrosine kinase,(BTK)
AO Vassilev, FM Uckun - Current pharmaceutical design, 2004 - ingentaconnect.com
… tyrosine kinases as potential drug targets in a number of diseases and deficiencies in the
following way: “…there is a long list of tyrosine kinases … therapeutic potentials of BTK inhibitors. …
following way: “…there is a long list of tyrosine kinases … therapeutic potentials of BTK inhibitors. …
Limitations to the therapeutic potential of tyrosine kinase inhibitors and alternative therapies for kidney cancer
H Kamli, L Li, GC Gobe - Ochsner Journal, 2019 - ochsnerjournal.org
… Resistance to the therapeutic potential of TKIs can be acquired or intrinsic. Alternative
therapies include other small molecule drugs and immunotherapy based on immune checkpoint …
therapies include other small molecule drugs and immunotherapy based on immune checkpoint …
Therapeutic potential of tyrosine kinase 2 in autoimmunity
Y Liang, Y Zhu, Y Xia, H Peng, XK Yang… - … on Therapeutic …, 2014 - Taylor & Francis
Introduction: Tyrosine kinase 2 (Tyk2) is a Janus kinase family member that is crucial for
signaling transduction in response to a wide variety of cytokines, including type I IFNs, IL-6, IL-10…
signaling transduction in response to a wide variety of cytokines, including type I IFNs, IL-6, IL-10…
Tyrosine kinase inhibitors and their unique therapeutic potentialities to combat cancer
… Many tyrosine kinase inhibitors are available as orally administered regimes like as … for
therapeutic. In the present review, we particularly focus on orally active tyrosine kinase inhibitors …
therapeutic. In the present review, we particularly focus on orally active tyrosine kinase inhibitors …
Bacterial tyrosine-kinases: Structure–function analysis and therapeutic potential
… BY-kinases (for Bacterial tyrosine-kinases) [28]. In this review, we will focus on functional
and structural aspects of BY-kinases and their potential utilization as therapeutic targets. …
and structural aspects of BY-kinases and their potential utilization as therapeutic targets. …
Drugging the undruggable: therapeutic potential of targeting protein tyrosine phosphatases
ZY Zhang - Accounts of chemical research, 2017 - ACS Publications
… together with protein tyrosine kinases, regulate tyrosine phosphorylation inside … tyrosine
phosphorylation offer enormous opportunities for targeted intervention. The therapeutic potential …
phosphorylation offer enormous opportunities for targeted intervention. The therapeutic potential …
SAR103168: a tyrosine kinase inhibitor with therapeutic potential in myeloid leukemias
B Bourrié, DL Brassard, S Cosnier-Pucheu… - Leukemia & …, 2013 - Taylor & Francis
… refueling the AML cell clones after front-line therapy. Based on these considerations, we
designed a study in which tyrosine kinase inhibitors were screened on the basis of their activity …
designed a study in which tyrosine kinase inhibitors were screened on the basis of their activity …
Therapeutic potential of protein tyrosine kinase 6 in colorectal cancer
… Since aberrant tyrosine kinase activities are directly linked with poor … therapeutic targets
under development. Already, there is a range of clinically approved therapeutic tyrosine kinase …
under development. Already, there is a range of clinically approved therapeutic tyrosine kinase …
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- protein tyrosine phosphatases therapeutic potential