Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes … of
DNA. Particularly, covalent complexes of topoisomerase 1 (TOP1) with DNA stabilized by DNA …

… Natural products have been developed into a large number … have been either natural products
or derived from natural product … to exploit the possibility that natural molecules might have …

… Herein, we report the discovery of the natural product oxynitidine scaffold as a novel
chemotype for the development of TOP1 and TDP1 inhibitors. Three kinds of analogues, …

… In the course of a screening program for Tdp1 inhibitors from a natural product library, we …
A total of 29 904 diverse natural product samples were screened employing a previously …

… A significant number of natural product-based drugs are … of biologically active derivatives
of natural products is to conjugate … Terpenophenols are natural product derivatives of mixed …

… DNA double-strand breaks. TTRAP is, to our knowledge, the first human 5′-tyrosyl DNA …
, and we suggest that this enzyme is denoted tyrosyl DNA phosphodiesterase-2 (TDP2). …

… on bioactive lead compounds from natural products, a high-throughput screening assay was
established and used to screen a prefractionated natural product library for Tdp1 inhibitors. …

… of oncological diseases involves the DNA repair enzyme tyrosyl-DNA phosphodiesterase
1 (Tdp1), which plays a key role in repairing damage to DNA caused by exposure to the …

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a repair enzyme for stalled DNA-topoisomerase
1 (Top1) cleavage complexes and other 3′-end DNA lesions. TDP1 is a perspective …

… Tyrosyl-DNA phosphodiesterase 2 (TDP2) plays an important role in the repair of DNA …
The sequent screening of our natural product library led to the identification of a new TDP2 …