… -coding region, has been linked more strongly to eye color. Both genes are located on …
These genes are of the greatest importance for eye color. Numerous ubiquitin ligases are coded …

… HECT domain and RCC1-like domain Containing protein 2 (HERC2) is a HECT E3 ubiquitin
ligase protein that is implicated in breast cancer, Prader-Willi syndrome, and eye color …

… The colour of mammalian fur, eyes and hair is mainly de… the action of E3 ubiquitin ligase
and deubiquitinating enzymes… coat coloration and addressing pigment-related diseases. …

… phenotypic association of AD with light eye colors, particularly blue eye color (Table I),
significant enrichment of genetic interactions between selected eye color genes and AD genes (…

… aspects of Drosophila eye development, including eye size, … fly eye size is regulated by
activity of two E3 ubiquitin ligases… requires activity of the E3 ubiquitin ligase, Ubr3 [52] which …

… Since RNAi of both Tcw and Tcst resulted in white eyes in pupae and adults, we examined
known eye-color mutants to determine if any represented defects in these two genes. Since …

… Eye color is largely determined by SNPs in specific genes, such as OCA2 melanosomal
transmembrane protein (OCA2), HECT and RLD domain containing E3 ubiquitin protein ligase 2 …

… activity and composition of ubiquitin ligases has been largely … specialized neurons in the eye
that capture and process light … , and in which ubiquitin and ubiquitination play a relevant role…

… Because Mid1 is an E3 ubiquitin ligase, we assume that Mid1 regulates Pax6 expression on
… -ubiquitination of Pax6. We also demonstrate that mid1 expression during eye development …

… is partially rescued, resulting in mice with normal eyes, a … the eye defect of the Mitf mi-vga9
mutation, and the coat color … the eye developmental defect but rescues the coat color defect …