Physiological functions of the HECT family of ubiquitin ligases
D Rotin, S Kumar - Nature reviews Molecular cell biology, 2009 - nature.com
… The E3 enzyme (a ubiquitin ligase) is responsible for substrate … E3 ubiquitin ligases act
as scaffolds to bring the E2 enzyme near the substrates and facilitate the transfer of ubiquitin to …
as scaffolds to bring the E2 enzyme near the substrates and facilitate the transfer of ubiquitin to …
Types of ubiquitin ligases
FE Morreale, H Walden - Cell, 2016 - cell.com
… The E3 ligases of the HECT (homologous to the E6AP carboxyl terminus) domain family
catalyze ubiquitin transfer to the substrate protein through a two-step reaction: ubiquitin is first …
catalyze ubiquitin transfer to the substrate protein through a two-step reaction: ubiquitin is first …
All in the ubiquitin family
M Hochstrasser - Science, 2000 - science.org
… subunit appears to depend on RUB1 ligase activity within the ubiquitin ligase itself (9). …
ligases, Rbx1. Rbx1 contains a RING finger motif, and this motif is required for the ubiquitination …
ligases, Rbx1. Rbx1 contains a RING finger motif, and this motif is required for the ubiquitination …
Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis
… Ubiquitin is then transferred from the E2-ubiquitin intermediate to a lysyl group on the … the
ubiquitin ligase or E3 enzyme. Uniquely, E3 ligases of the HECT domain class form a ubiquitin …
ubiquitin ligase or E3 enzyme. Uniquely, E3 ligases of the HECT domain class form a ubiquitin …
The E3 ubiquitin ligase gene family in plants: regulation by degradation
E Mazzucotelli, S Belloni, D Marone… - Current …, 2006 - ingentaconnect.com
… ubiquitin ligase gene family suggests its role giving specificity to the system, each E3 ubiquitin
ligase acting for the ubiquitination … the large family of E3 ubiquitin ligases in relation to the …
ligase acting for the ubiquitination … the large family of E3 ubiquitin ligases in relation to the …
U-box proteins as a new family of ubiquitin ligases
S Hatakeyama, IN Kei-ichi - Biochemical and biophysical research …, 2003 - Elsevier
… Ubiquitin-protein ligases (E3s) determine the substrate … into two families, the HECT and
RING-finger families. The U-box … Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion …
RING-finger families. The U-box … Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion …
Regulation of TGF‐β family signaling by E3 ubiquitin ligases
Y Inoue, T Imamura - Cancer science, 2008 - Wiley Online Library
… Arkadia, a RING-type E3 ubiquitin ligase, induces the ubiquitination and degradation of … -β
family signaling. Abnormalities in E3 ubiquitin ligases that control components of TGF-β family …
family signaling. Abnormalities in E3 ubiquitin ligases that control components of TGF-β family …
A novel family of membrane-bound E3 ubiquitin ligases
M Ohmura-Hoshino, E Goto, Y Matsuki… - Journal of …, 2006 - academic.oup.com
… A novel E3 ubiquitin ligase family that consists of viral E3 ubiquitin ligases (E3s) and their
mammalian homologues was recently discovered. These novel E3s are membrane-bound …
mammalian homologues was recently discovered. These novel E3s are membrane-bound …
RBR E3 ubiquitin ligases: new structures, new insights, new questions
… share common features with both the larger RING and HECT (homologous with E6-associated
protein C-terminus) E3 ligase families, directly catalysing ubiquitin transfer from an …
protein C-terminus) E3 ligase families, directly catalysing ubiquitin transfer from an …
[HTML][HTML] The HECT family of E3 ubiquitin ligases: multiple players in cancer development
… is then transferred to a specific Cys residue of one of a family of E2 ubiquitin-… The E3 ubiquitin
ligases (E3s) play a critical role in the ubiquitin conjugation cascade by recruiting ubiquitin-…
ligases (E3s) play a critical role in the ubiquitin conjugation cascade by recruiting ubiquitin-…