… of first-line ART like Uganda, our findings suggest that one in three children on first-line
ART are likely to develop virological treatment failure after the first 24 months of therapy. …

… Acute and chronic toxicity, drug intolerance, poor adherence, and treatment failure remain
the … of cART treatment failure in 2 pediatric cohorts from Mozambique and Uganda during a 5-…

… The odds of treatment failures were four times higher among children who started treatment
on … In addition, there was a perception of increasing treatment failure among children treated …

… children are severely immune suppressed. Our finding of greater viral failure among male
compared with female children … Our data suggest that viral failure occurring 6 months or more …

… However, the high rate of PDR and its association with treatment failure that we found in
our cohort of older children (median age 4.9 years) suggest that PI-based first-line ART for …

… , we tried to identify children at risk for failure after 24 months of treatment, which is a unique
… to the ART regimens and therefore acute treatment failure, we think our approach is of value. …

… The number of children with treatment failure in our cohort … of Ugandan children on second-line
ART were favorable, and no PI mutations were detected in children with treatment failure …

… Treatment outcomes were classified according to 2005 WHO guidelines as early treatment
failure (complicated malaria or failure … with early treatment failure or late clinical failure within …

… risk factors for mefloquine treatment failure.… , failure to control for confounding effects.In this
report, we analyze the predictive value of hostrelated factors for chloroquine treatment failure …

… Perhaps, our most concerning finding was that the WHO immunologic criteria for
treatment failure detected virologic failure in only 1 (6%) of 16 children. The WHO criteria are …