… As one can easily infer, uterine fibroids can … use of ulipristal acetate (UPA), an oral selective
progesterone modulator (SPRM), for the pharmacological management of uterine fibroids. …

… fibroids and excessive uterine bleeding to receive 3 months of daily therapy with oral ulipristal
acetate … once-monthly intramuscular injections of leuprolide acetate (at a dose of 3.75 mg). …

… in women with uterine fibroids, but its efficacy is reduced in patients with a distorted uterus
(8). Since February 2012, ulipristal acetate (UPA) is also approved in Europe for preoperative …

… of ulipristal acetate for the treatment of uterine fibroids. PEARL IV was conducted in 46 study
sites across 11 countries from June 2012 to February 2014. The study was approved by the …

… fibroid proliferation, raising the possibility that progesterone receptor modulators could
inhibit fibroid growth; this research has culminated in the emergence of ulipristal acetate (UA), a …

… of repeated 12-week courses of 5 or 10 mg daily ulipristal acetate for intermittent treatment
of symptomatic uterine fibroids. … Uterine fibroids are benign smooth muscle tumors of the …

… This section focuses on the tolerability of ulipristal acetate in women with uterine fibroids
with data mostly derived from the two 13-week, randomized, double-blind, phase III PEARL …

… for the treatment of uterine fibroids has been well established [2]. Ulipristal acetate (UPA) …
control excessive bleeding due to uterine fibroids and may lead to fibroid shrinkage [3] [4]. …

… Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal
acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (…

… in reducing the size of uterine fibroids and the amount of bleeding, but … , ulipristal acetate
(UPA). In 2 Phase III randomized double-blind controlled clinical trials, 546 patients with uterine …