Clinical outcomes of gefitinib and erlotinib in patients with NSCLC harboring uncommon EGFR mutations: A pooled analysis of 438 patients

C Wang, K Zhao, S Hu, W Dong, Y Gong, M Li, C Xie - Lung Cancer, 2022 - Elsevier
patients with NSCLC harboring uncommon EGFR mutationsPatients with compound
mutations had an ORR of 56.3 % … these in patients with single uncommon EGFR mutation, which …

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

S Ikemura, H Yasuda, S Matsumoto… - Proceedings of the …, 2019 - National Acad Sciences
… in analyzing complex cancer mutations. Thus, the … patients carrying rare EGFR mutations
in the clinical setting. Here, we propose an insight to overcome mutation diversity in lung cancer

Rare and complex mutations of epidermal growth factor receptor, and efficacy of tyrosine kinase inhibitor in patients with non-small cell lung cancer

B Keam, DW Kim, JH Park, JO Lee, TM Kim… - International journal of …, 2014 - Springer
… them, EGFR mutation status was examined in 430 patients. Of the 430 patients, 306 (71.1 %)
who had any EGFR mutation … In conclusion, rare EGFR mutations showed a heterogeneous …

Common and rare EGFR and KRAS mutations in a Dutch non-small-cell lung cancer population and their clinical outcome

GSMA Kerner, E Schuuring, J Sietsma… - PloS one, 2013 - journals.plos.org
patients with one of the other 4 rare EGFR mutations (… patients an EGFR or KRAS mutation,
respectively. We also identified 5 novel or rare EGFR mutations and 2 novel KRAS mutations

[HTML][HTML] Afatinib for the treatment of NSCLC harboring uncommon EGFR mutations: a database of 693 cases

JCH Yang, M Schuler, S Popat, S Miura… - Journal of Thoracic …, 2020 - Elsevier
uncommon EGFR mutations. This pooled analysis assessed the activity of afatinib in 693
patients with tumors harboring uncommon EGFR mutations … -small-cell lung cancer (EURTAC): …

[PDF][PDF] Successful treatment of a patient with lung adenocarcinoma harboring compound EGFR gene mutations, G719X and S768I, with Afatinib

N Kutsuzawa, F Takahashi, K Tomomatsu… - Tokai J Exp Clin …, 2020 - mj-med-u-tokai.com
… , and clinical data of EGFR-TKIs for cases with compound uncommon mutations are scarce.
… of a patient with lung adenocarcinoma harboring compound uncommon EGFR mutations, …

[HTML][HTML] Epidermal growth factor receptor mutations in lung adenocarcinoma

MD Siegelin, AC Borczuk - Laboratory investigation, 2014 - Elsevier
… , STAT3 is phosphorylated and activated by activating EGFR mutations in lung adenocarcinomas.
… In rare instances, the T790M mutation is a germline mutation. In a very small subset of …

Association of smoking status with non-small cell lung cancer patients harboring uncommon epidermal growth factor receptor mutation

HW Ko, SS Shie, CW Wang, CT Chiu… - Frontiers in …, 2022 - frontiersin.org
… status and sex in patients with uncommon EGFR mutation … higher in patients with uncommon
EGFR mutations than in … on the 399 patients carrying uncommon EGFR mutations but did …

Clinical activity of afatinib in patients with non–small-cell lung cancer harboring uncommon EGFR mutations: a Spanish retrospective multicenter study

T Moran, A Taus, E Arriola, C Aguado, M Dómine… - Clinical Lung Cancer, 2020 - Elsevier
EGFR del19 and L858R mutations are detected in approximately 85% to 90% of all the
EGFR-mutated lung adenocarcinomas and … to tyrosine kinase inhibitors (TKIs) targeting EGFR. …

Uncommon V599E BRAF mutations in Japanese patients with lung cancer

H Sasaki, O Kawano, K Endo, E Suzuki… - Journal of Surgical …, 2006 - Elsevier
mutations in Japanese lung cancer patients. The study included 129 surgically removed
lung cancer … We detected the 43 EGFR mutations, including 19 at exon 19 and 20 at exon 21 …