Epidemiological studies have shown that ageing is a major non-reversible risk factor for
cardiovascular disease. Vascular ageing starts early in life and is characterized by a gradual …

… In this review, we reviewed the underlying mechanisms of PARP inhibitor resistance in
detail and summarized the potential strategies to overcome PARPi resistance and increase …

Increasing awareness of atrial fibrillation (AF) and its impact on public health revives
interest in identification of noninvasive markers of predisposition to AF and ECG‐based risk …

Pain can be both a cause and a consequence of sleep deficiency. This bidirectional relationship
between sleep and pain has important implications for clinical management of patients, …

Background: The study of tinnitus mechanisms has increased tenfold in the last decade. The
common denominator for all of these studies is the goal of elucidating the underlying neural …

… and cellular metabolism and the implications of these findings for brain functions and ADHD
symptoms. We also summarize the clinical implications of these observations and point to …

… underlying mechanisms remain to be explored. Atherosclerotic plaques which are more prone
to destabilisation and rupture, leading to clinical … the underlying inflammatory mechanisms…

… Therefore, we recommend considering the fluctuations in TSH levels and their potential
underlying biological mechanisms in clinical practice and when performing clinical research. For …

… In this study, we investigated the characteristics and underlying mechanisms of the … the
characteristics, underlying mechanisms, as well as the clinical implications of the ECG …

Administration of quinidine with digoxin increased serum digoxin concentrations in 79
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …