Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook

SM Chowdhury, L Abou-Elkacem, T Lee, J Dahl… - Journal of Controlled …, 2020 - Elsevier
… The mechanism behind the enhanced permeability is the temporary creation of pores in cell
… -intensity ultrasound and microbubbles or cavitation agents. At low ultrasound intensities (0.3…

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms

I Lentacker, I De Cock, R Deckers, SC De Smedt… - Advanced drug delivery …, 2014 - Elsevier
… of ultrasound settings used and corresponding microbubblemechanisms contributing to
sonoporation are categorized according to three ultrasound settings: i) low intensity ultrasound

How do microbubbles and ultrasound interact? Basic physical, dynamic and engineering principles

M Azmin, C Harfield, Z Ahmad… - Current …, 2012 - ingentaconnect.com
… In high intensity focused ultrasound (HIFU) surgery, microbubbles … At lower ultrasound
intensities, microbubbles have been … The underlying mechanisms have yet to be fully understood …

The role of ultrasound-driven microbubble dynamics in drug delivery: from microbubble fundamentals to clinical translation

S Roovers, T Segers, G Lajoinie, J Deprez, M Versluis… - Langmuir, 2019 - ACS Publications
… fundamental microbubble studies with a focus on ultrasound-driven microbubble behavior
and … long pulses on targeted microbubbles that are bound to an underlying surface, secondary …

Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery

P Qin, T Han, CH Alfred, L Xu - Journal of controlled release, 2018 - Elsevier
… outlines the underlying bioeffects and the related biological regulatory mechanisms involved
in … Overview of the underlying mechanisms for the opening and restoration of intercellular …

[HTML][HTML] Mechanisms underlying sonoporation: Interaction between microbubbles and cells

Y Yang, Q Li, X Guo, J Tu, D Zhang - Ultrasonics Sonochemistry, 2020 - Elsevier
… the underlying mechanismsultrasound contrast agents, such as micro/nano-bubbles/droplets,
to serve as cavitation nuclei [12]. Ultrasound contrast agents are generally microbubbles

Micromanipulation of endothelial cells: ultrasound-microbubble-cell interaction

A Van Wamel, A Bouakaz, M Versluis… - Ultrasound in medicine & …, 2004 - Elsevier
… The underlying mechanisms are still unknown. One hypothesis is that oscillating microbubbles
cause … This technical note reveals the interaction between oscillating microbubbles and …

Ultrasound and microbubble-induced intra-and intercellular bioeffects in primary endothelial cells

LJM Juffermans, A van Dijk, CAM Jongenelen… - Ultrasound in medicine …, 2009 - Elsevier
… and cells, as well as increase our understanding about the mechanisms behind enhanced
cellular internalization of extracellular molecules. This is essential for designing new …

Physical principles of microbubbles for ultrasound imaging and therapy

E Stride - Cerebrovascular Diseases, 2009 - karger.com
… More extensive reviews of the clinical applications of microbubbles may be found in Becher
… types of microbubble agent, their physical behaviour and the mechanisms underlying their …

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

N Sheikov, N McDannold, N Vykhodtseva… - Ultrasound in medicine …, 2004 - Elsevier
Local blood-brain barrier (BBB) opening is an advantageous approach for targeted drug
delivery to the brain. Recently, it has been shown that focused ultrasound (US) exposures (…