… She was an early leader in the field of targeted protein degradation, pioneering approaches
to monitor cellular kinetics of degradation, understand mechanism of action, and most …

… understanding the mechanisms of targeted protein degradation, particularly in understanding
… , and other factors that contribute to efficient degradation. This review will focus on how …

… understanding and novel chemistry has not only provided clinical proof of concept for targeted
protein degradation … current landscape of targeted protein degradation approaches and …

… target intracellular proteins. Lysosome-dependent TPD strategies could degrade membrane
proteins, extracellular proteins, and protein … introduction of protein degradation mechanisms. …

… protein degradation systems. This review highlights the most recent advances in targeted
protein … novel tool to specifically degrade endogenous genetically unmodified target protein. …

… exploited for targeted protein degradation, and expansion of knowledge in this area is a key
opportunity. Here, we briefly discuss lessons learned about targeted protein degradation in …

… We explain the current understanding of the mechanism of each technology and discuss
the outstanding questions in each approach. Lastly, we discuss the future of TPD and its …

… Addressing the challenge related to mechanism and selectivity will significantly enhance
our understanding of targeted degradation of difficult but still properly “behaving” …

… system to mediate target protein degradation. This then limits protein targets to cytosolic …
-based degraders, while further enhancing our understanding of essential biological factors …

… In this review, we summarize our current understanding of biological and synthetic
regulation of protein degradation and share our view on how these diverse mechanisms have …