… We want to emphasize that we are not proposing that water is a good solvent for all unfolded
proteins. It is clear, for example, that low-diversity or poorly mixed sequences sometimes …

… By comparing his results to experimental data, he concluded that ‘…the overall properties
of unfolded proteins can be usefully described by a random coil model and that an unfolded …

… and around unfolded proteins, have major implications for how the field views the role of
water removal during folding. X-ray crystallography has long been used to analyze …

… sampled by peptides and unfolded proteins is largely determined by their interaction with
water. It has been a long-standing goal to capture these solute-water energetics accurately and …

… We employ the idea that the protein–solvent interaction will be proportional to … water
properties is found to be very model dependent, however. The maximally exposed unfolded protein …

… water is a good solvent or a poor solvent for proteins.6, 24 Intuitively, one might expect that
water is a good solvent if, on average, residue backbones have three water-accessible sites …

… of ubiquitin varying the solvent conditions, temperature, and starting protein conformation.
Our main goal in this communication is description of the partially unfolded state of ubiquitin in …

… of an unfolded protein in different solvents including 6.65 M GuHCl and water at low and …
as an example of unfolded protein because it has been shown that this protein is completely …

… the protein and the water solvent. We study the dynamics of water in aqueous solutions of
several globular proteins at different degrees of urea-induced unfolding, using polarization-…

… , we exhaustively dialyzed the proteins against distilled water with subsequent lyophilization.
… Urea solutions were used as solvents for the proteins investigated in this study. The …