… interacting with dysfunctional mitochondria upon reperfusion. Recently, this … mechanism.
Here we survey the metabolic factors underlying IR injury and propose a unifying mechanism …

… that the underlying mechanisms of reperfusion injury seem to be shared among heart,
brain, liver, intestine, skeletal muscle and more, has contributed significantly to unifying the …

… First, many think that ischemia itself is the detrimental factor, and the only role of reperfusion
is to inflict the ‘‘coup de grace.’’This report suggests that ischemia creates a progressive …

… The first ischemia reperfusion injury (I/R) was recognized in 1970s and the term indicates
tissue ischemia with inadequate oxygen supply followed by successful reperfusion initiating a …

… mechanism of MIRI has not been fully elucidated. The present study reviews the mechanisms
… Based on current understanding of the pathophysiological mechanisms of MIRI, the …

… Ischemia-reperfusion (IR) injury occurs when the blood supply to an organ is interrupted (ischemia)
and then re-established (reperfusion), leading to a “burst” of ROS from mitochondria […

… reperfusion injury. Although multiple cellular and molecular pathways contribute and regulate
tissue/organ damage, integration of different players into a unified mechanism … mechanism …

… The purpose of this review is to integrate available data on the effect of brain ischemia/reperfusion
(I/R) on mitochondrial complex I. Complex I is a key component of the mitochondrial …

… DHA attenuates hepatic ischemia reperfusion injury by inhibiting pyroptosis and
activating … A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion …

… Injury” section we extend this concept to unify these three events into a novel paradigm that
… caused by ischemia/reperfusion. However, before presenting this model of reperfusion injury…