… , suggesting that ROS production during IR occurs by a defined mechanism. Here we survey
the metabolic factors underlying IR injury and propose a unifying mechanism for its causes …

… for the active site chemistry, and superoxide and H 2 O 2 … unified mechanism for superoxide
and H 2 O 2 production by … understanding how rates of ROS production by complex I in …

… Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified
mechanism … Hence, there is considerable interest in understanding the mechanisms by which …

… In addition, we found that the model fit the data better when this site was deprotonated for
the superoxide producing reactions. Based on model analysis, the primary source of ROS …

… hydrogen peroxide and superoxide production at any NADH … of NADH concentration,
superoxide production rate shows a … dependence of hydrogen peroxide production is seen with …

… Our results show that a single unifying mechanism of induction, increased production of
superoxide … -induced mitochondrial superoxide overproduction or dismutate the superoxide so …

… for mitochondrial superoxide production, but as mentioned, aconitase deserves a dedicated
discussion that is found next. Beyond the more likely scenarios that superoxide will react …

… Site-specific suppressors of superoxide production (named … reported; however, their
mechanism of action remains elusive. … for the suppression of superoxide production during reverse …

Flavocytochrome b 558 is the catalytic core of the respiratory-burst oxidase, an enzyme complex
that catalyzes the NADPH-dependent reduction of O 2 into the superoxide anion O 2 - in …

… using a unified, coherent, and consistent framework. Thus, the origin of … superoxide production
by these sites IQ and IF and making complex I the greatest combined source of superoxide…