… In the past decade, islet inflammation has emerged as a … recruit macrophages into islets, thus
augmenting inflammation. Limited … our understanding of islet inflammatory pathways and to …

… Multiple human studies of T2D have shown that targeting islet inflammation has the potential
… shown that chronic inflammation is a common and potentially unifying mechanistic cause of …

… as insulin target organs. However, the nature of islet inflammation and its effects on islet …
Moreover, the immune cell profiles of human islets in healthy and type 2 diabetic conditions are …

… These principles may be a unifying feature in monogenetic and polygenetic forms of …
decay of extra-XBP1 target mRNAs such as the mRNAs encoding secretory target cargo, ie, …

… will be to agree upon whether a unifying nomenclature to classify tissue macrophages based
… on all endocrine cells if islet inflammation is to be effectively targeted to restore functional …

… It comprises gene expression (bulk RNA sequencing) and genome-wide genetic variation
data (GWAS) from human pancreatic islets, as well as some of the target tissues for insulin. …

… system and inflammation signature … islet stressor conditions (such as hypoxia), which was
previously associated with the diabetic NOD phenotype more as a target of the inflammatory …

… beta cell dysfunction with 12-LO activation and NOX-1-induced ROS in a unifying pathway.
… Inhibition of this pathway is a candidate target to preserve and protect beta cell mass in …

… primed enhancers, inflammatory response and islet-specific … Thus, we applied targeted
chromosome capture with unique … measure interaction intensities in human islets before and after …

… a unified risk model for different diabetes variants [6]. … In T1D, islet autoantibodies and genomic
risk have been … those T cells enriched at the target site of inflammation in T2D are antigen-…