Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
… Finally, the integration of metabolomic profiles with … methodological pipeline of an untargeted
metabolomic study. This … generate the sample metabolic information (ie, metabolic features)…

Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
… studies allows better understanding of changes in the metabolic profiles of phenotypes. …
in untargeted metabolomics profiles is much simpler than in targeted metabolomics profiles. In …

Serum metabolic profiling analysis of chronic gastritis and gastric cancer by untargeted metabolomics

L Yu, Q Lai, Q Feng, Y Li, J Feng, B Xu - Frontiers in Oncology, 2021 - frontiersin.org
Metabolic profiling performed in the present study included sample preparation, metabolite
extraction, and LC/MS analysis. A total of 123 serum samples and 15 QC samples were used …

Separation strategies for untargeted metabolomics

GJ Patti - Journal of separation science, 2011 - Wiley Online Library
… A major distinguishing factor, however, between proteomic and metabolomic profiling is the
LC method used. Although chromatography serves similar purposes in each approach, the …

Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS

P Masson, AC Alves, TMD Ebbels… - Analytical …, 2010 - ACS Publications
… As our aim was to perform untargeted metabolic profiling of liver samples and therefore
extract thousands of metabolites encompassing a wide range of chemical structures, it was …

Meta-analysis of untargeted metabolomic data from multiple profiling experiments

GJ Patti, R Tautenhahn, G Siuzdak - Nature protocols, 2012 - nature.com
untargeted metabolomic data. It is designed to identify the differences between metabolic
profiles … interesting metabolite features from large untargeted metabolomic data sets before the …

Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data

LR Thistlethwaite, X Li, LC Burrage, K Riehle… - Scientific reports, 2022 - nature.com
… full-profile models were defined to be ones that considers all frequently detected metabolites
in untargeted metabolomics profiles, … , we used untargeted metabolomics profiling data from …

Untargeted GC-MS Metabolomics

MEP Papadimitropoulos, CG Vasilopoulou… - Metabolic profiling …, 2018 - Springer
… of the metabolic profile, in the case of untargeted metabolomic analyses, mass … metabolic
profiling contain a large number of unidentified peaks, which cannot be related to the metabolic

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

E Crestani, H Harb, LM Charbonnier, J Leirer… - Journal of Allergy and …, 2020 - Elsevier
… We sought to apply untargeted metabolomic profiling to … untargeted serum metabolomic
profiling of children with distinct atopic phenotypes led to identification of a unique metabolomic

Comparison of untargeted metabolomic profiling vs traditional metabolic screening to identify inborn errors of metabolism

N Liu, J Xiao, C Gijavanekar, KL Pappan… - JAMA Network …, 2021 - jamanetwork.com
… a clinical untargeted metabolomic profiling method with a higher diagnostic screening rate
for IEMs (approximately 6-fold higher) that detected more IEMs than the traditional metabolic