Structural and compositional features of untranslated regions of eukaryotic mRNAs
… statistical analysis of the mRNA untranslated regions for various groups of … in mammal
mRNAs. About the same length ratio, 2.5, was observed for non-mammalian vertebrate mRNAs, …
mRNAs. About the same length ratio, 2.5, was observed for non-mammalian vertebrate mRNAs, …
The role of the 3'untranslated region in post-transcriptional regulation of protein expression in mammalian cells.
E Matoulkova, E Michalova, B Vojtesek, R Hrstka - RNA biology, 2012 - Taylor & Francis
… untranslated regions (UTRs) at the 3'end of mRNA transcripts contain important sequences
that influence the fate of mRNA … in the regulatory processes in mammalian cells. In addition to …
that influence the fate of mRNA … in the regulatory processes in mammalian cells. In addition to …
Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs
… sites located in the 3′ untranslated regions (3′ UTRs) of mRNAs to downregulate their
expression when the appropriate miRNA is bound to target mRNA. To establish the functional …
expression when the appropriate miRNA is bound to target mRNA. To establish the functional …
Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA
KH Asrani, JD Farelli, MR Stahley, RL Miller… - RNA biology, 2018 - Taylor & Francis
… -life of exogenously administered mRNA and subsequent protein production. Modulation
of untranslated regions (UTR) represents one approach to enhance both mRNA stability and …
of untranslated regions (UTR) represents one approach to enhance both mRNA stability and …
Evolutionary dynamics of mammalian mRNA untranslated regions by comparative analysis of orthologous human, artiodactyl and rodent gene pairs
A Larizza, W Makalowski, G Pesole, C Saccone - Computers & chemistry, 2002 - Elsevier
… To evaluate the incidence of insertions and deletions during evolution of mammalian mRNAs,
we have performed a study on indel frequency in CDSs and UTRs. Terminal gaps (due to …
we have performed a study on indel frequency in CDSs and UTRs. Terminal gaps (due to …
[HTML][HTML] The untranslated regions of mRNAs in cancer
SL Schuster, AC Hsieh - Trends in cancer, 2019 - cell.com
… We show a theoretical mRNA schematic highlighting a few salient examples that have
implications in cancer: upstream open reading frames (uORFs), internal ribosome entry sites (…
implications in cancer: upstream open reading frames (uORFs), internal ribosome entry sites (…
Alternative mechanisms of initiating translation of mammalian mRNAs
RJ Jackson - Biochemical Society Transactions, 2005 - portlandpress.com
… ′-untranslated regions had so many AUG triplets that were apparently silent as initiation sites.
The discovery that insertion of these 5′-untranslated regions … that mammalian ribosomes …
The discovery that insertion of these 5′-untranslated regions … that mammalian ribosomes …
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
D Caput, B Beutler, K Hartog… - Proceedings of the …, 1986 - National Acad Sciences
… mRNAs, except the lymphotoxin mRNA, lack homology to the TNF mRNAs in the coding
region… The consensus sequence is uncommon among mammalian mRNAs in general, but it …
region… The consensus sequence is uncommon among mammalian mRNAs in general, but it …
A guide to design and optimization of reporter assays for 3′ untranslated region mediated regulation of mammalian messenger RNAs
J Van Etten, TL Schagat, AC Goldstrohm - Methods, 2013 - Elsevier
… specific mRNA sequences that are often found in untranslated regions. The potential for vast
post-… control exists: mammalian mRNAs contain extensive untranslated regions and their …
post-… control exists: mammalian mRNAs contain extensive untranslated regions and their …
Efficient cap-dependent translation of mammalian mRNAs with long and highly structured 5′-untranslated regions in vitro and in vivo
SE Dmitriev, DE Andreev, ZV Adyanova, IM Terenin… - Molecular biology, 2009 - Springer
… to a capped 5' end of eukaryotic mRNA with the help of special … the 5'-untranslated region
(5'-UTR) of the mRNA for an initiator … is the same in mRNAs, those with long 5'-UTRs are less …
(5'-UTR) of the mRNA for an initiator … is the same in mRNAs, those with long 5'-UTRs are less …
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