… receptors are highly up-regulated under several stressful … up-regulation. In this study,
we demonstrate that Pg-LPS injection into the rat paw resulted in a marked functional up-regulation …

… COX-2 mRNA expression was analyzed in hindfoot tissue after adjuvantinduced peripheral
inflammation in ipsilateral inflamed paws (a+b) and contralateral uninflamed paws (c+d). …

… Our results suggest that the rat paw oedema induced by des-Arg 9 -BK after id injection of
IL-1β or TNFα involves the secondary production of other cytokines, since the increase in B 1 -…

… Consistent with previous findings,15, 18we found that unilateral injection of CFA into the
plantar surface of rat hindpaw significantly increased paw diameter and produced a profound …

… We have established a subacute pain model by short intermittent heat stimulation of the rat
hind paws, or by a sequential mustard oil and heat stimulation, and have demonstrated that …

… The current results also extend and confirm our previous results that upregulation of B1
receptors in this model is associated with downregulation of B2 receptors (Campos & Calixto, …

… In agreement with such data, results of the present study show that the up-regulation of B 1
receptor-mediating rat paw edema, after ID injection of IL-1β or TNFα, was almost completely …

… in rat paw, induced by LPS and characterized by paw oedema, neutrophil recruitment,
cytokine production, activation of MAP kinases and NF-κB and up-regulated expression of kinin B …

… (100 μl, 4%) was injected into the plantar side of a hind paw of the rat. In addition, four rats
were treated only with intrathecal ODQ (10 μg) and another four rats received no treatment. …

… In brief, the lateral-plantar site of the right hind paw was … When the rat withdrew its hind paw,
the paw withdrawal … Our study exhibited an upregulation of TNF-α and IL-6 in rats after CCI …