Uric acid as a target of therapy in CKD

DI Jalal, M Chonchol, W Chen, G Targher - American journal of kidney …, 2013 - Elsevier
… Although uric acid also may be linked to cardiovascular disease and mortality in … CKD,
this review focuses only on uric acid as a potential therapeutic target to prevent kidney disease

The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD

Y Sato, DI Feig, AG Stack, DH Kang… - Nature Reviews …, 2019 - nature.com
… urate levels and CKD. These findings have created uncertainty with regard to the true role
of uric acid in the development and progression of CKD and whether ULT is warranted 26,43 . …

Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis

X Liu, T Zhai, R Ma, C Luo, H Wang, L Liu - Renal failure, 2018 - Taylor & Francis
… levels were associated with the progression of chronic kidney disease (CKD) … serum uric
acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD

Uric acid and long-term outcomes in CKD

M Madero, MJ Sarnak, X Wang, T Greene… - American Journal of …, 2009 - Elsevier
… between uric acid level and mortality is independent of traditional CVD risk factors. … of
CKD, 16 it is possible that uric acid level also is a risk factor for progression of kidney disease. …

Effects of uric acid-lowering therapy in patients with chronic kidney disease: A meta-analysis

X Su, B Xu, B Yan, X Qiao, L Wang - PloS one, 2017 - journals.plos.org
… of uric acid-lowering therapy on populations with CKD found in this study were limited, a
similar association between kidney function and the benefit of uric acid-lowering therapy has …

Update on uric acid and the kidney

GK Ramos, DS Goldfarb - Current Rheumatology Reports, 2022 - Springer
… In this review, we report on new findings regarding associations of uric acid with kidney
health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and …

Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis

B Bose, SV Badve, SS Hiremath… - Nephrology Dialysis …, 2014 - academic.oup.com
… association between serum uric acid levels and progression of chronic kidney disease (CKD). …
(RCTs) concerning the benefits and risks of uric acid-lowering therapy on renal outcomes. …

Uric acid in CKD: has the jury come to the verdict?

B Bonino, G Leoncini, E Russo, R Pontremoli… - Journal of …, 2020 - Springer
… (ULT) in CKD patients. We believe that current results of clinical studies support the usefulness
of routine measurement of serum uric acid in patients with CKD and that initiation of ULT …

The role of uric acid in chronic kidney disease patients

YP Hsieh, CC Chang, Y Yang, YK Wen, PF Chiu… - …, 2017 - Wiley Online Library
… by averaging all the uric acid measurements during the … uric acid may vary greatly over
time, especially after the CKD education, the mean of the first two consecutive serum uric acid

Challenges of conducting a trial of uric-acid-lowering therapy in CKD

SV Badve, F Brown, CM Hawley, DW Johnson… - Nature Reviews …, 2011 - nature.com
… of developing incident CKD was 26% higher in individuals with a serum uric acid level … uric
acid level >526 μmol/l (>9 mg/dl), compared with the risk in individuals with a serum uric acid