[HTML][HTML] The role of xanthine oxidoreductase and uric acid in metabolic syndrome

MG Battelli, M Bortolotti, L Polito, A Bolognesi - Biochimica et Biophysica …, 2018 - Elsevier
xanthine oxidoreductase (XOR) mainly has the function of catalyzing the conversion of
hypoxanthine to xanthine and the latter to uric acid, … Since uric acid is an irreversible product, XOR …

Uric acid and xanthine oxidoreductase in wound healing

ML Fernandez, Z Upton, GK Shooter - Current rheumatology reports, 2014 - Springer
… findings provide evidence that xanthine oxidoreductase may have a … of xanthine oxidoreductase
and uric acid accumulation in the wound site, and the effect of xanthine oxidoreductase

Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases

H Sekizuka - Hypertension Research, 2022 - nature.com
… produce xanthine and xanthine to produce UA. XOR has only been found to act as xanthine
… On the other hand, XOR can be reversibly converted into XDH and xanthine oxidase (XO) in …

[HTML][HTML] Xanthine oxidoreductase: One enzyme for multiple physiological tasks

M Bortolotti, L Polito, MG Battelli, A Bolognesi - Redox biology, 2021 - Elsevier
Xanthine oxidoreductase (XOR) is a … and xanthine to uric acid is ensured by the xanthine
dehydrogenase activity (XDH, EC 1.17.1.4), but only mammals possess the xanthine oxidase (…

New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity

M Furuhashi - American Journal of Physiology …, 2020 - journals.physiology.org
… serum uric acid level only exists for gout and nephrolithiasis. Xanthine oxidoreductase (XOR),
but not uric acid, could be a causal risk factor for cardiovascular disease (CVD) and CKD. …

[HTML][HTML] Hyperuricemia-related diseases and xanthine oxidoreductase (XOR) inhibitors: an overview

C Chen, JM Lü, Q Yao - Medical science monitor: international …, 2016 - ncbi.nlm.nih.gov
Uric acid is the final oxidation product of purine metabolism in humans… Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, …

The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors

N Liu, H Xu, Q Sun, X Yu, W Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
… decreases in urinary uric acid excretion, confirming inhibition of xanthine oxidase activity by
… /day) due to its selectivity towards xanthine oxidase. In a recent study of Japanese patients, …

Xanthine oxidoreductase in cancer: more than a differentiation marker

MG Battelli, L Polito, M Bortolotti… - Cancer medicine, 2016 - Wiley Online Library
… Introduction: Biology of Xanthine Oxidoreductase Xanthine oxidoreductase catalyzes the
oxidation of hypoxanthine to xanthine and of xanthine to uric acid, that is, the last two steps of …

Identification of uric acid and xanthine oxidase in atherosclerotic plaque1

P Patetsios, M Song, WP Shutze, C Pappas… - American Journal of …, 2001 - ajconline.org
uric acid or xanthine oxidase in atherosclerotic vessels. This study qualitatively and quantitatively
measures uric acid … the presence of xanthine oxidase and uric acid crystals within the …

Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients

A Nakatani, S Nakatani, E Ishimura, T Murase… - Scientific reports, 2017 - nature.com
Xanthine oxidoreductase (XOR) is a ubiquitous enzyme that catalyzes the oxidation of both
hypoxanthine to xanthine and xanthine to uric acid in the purine degradation pathway 4,5 . It …