The use of digoxin in patients with worsening chronic heart failure: reconsidering an old drug to reduce hospital admissions

AP Ambrosy, J Butler, A Ahmed… - Journal of the American …, 2014 - jacc.org
Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management
of patients with heart failure … from the foxglove plant, digoxin increases ejection fraction, …

Contemporary use of digoxin in the management of cardiovascular disorders

M Gheorghiade, DJ Van Veldhuisen, WS Colucci - Circulation, 2006 - Am Heart Assoc
… This study enrolled patients in sinus rhythm with reduce systolic function and stable heart
failure symptoms who were receiving digoxin and diuretics. Patients in whom …

The contemporary use of digoxin for the treatment of heart failure

GS Francis - Circulation: Heart Failure, 2008 - Am Heart Assoc
… the use of digoxin to control AF when it is observed in patients with heart failure with normal
… threshold for using digoxin to control heart rate as opposed to cardioversion in patients with …

Association of serum digoxin concentration and outcomes in patients with heart failure

SS Rathore, JP Curtis, Y Wang, MR Bristow… - Jama, 2003 - jamanetwork.com
… the efficacy of digoxin therapy for patients with heart failure, found that digoxin therapy had
no effect on mortality but modestly reduced hospitalizations due to worsening heart failure. …

Digoxin use and heart failure outcomes: results from the valsartan heart failure trial (Val‐HeFT)

J Butler, IS Anand, MA Kuskowski… - … Heart Failure, 2010 - Wiley Online Library
… No benefit with digoxin use was observed in this study, underscoring the need to reassess
the role of digoxin in the contemporary management of heart failure. Congest Heart Fail. 2010;…

Effectiveness and safety of digoxin among contemporary adults with incident systolic heart failure

JV Freeman, J Yang, SH Sung… - … Quality and Outcomes, 2013 - Am Heart Assoc
… HF toward more ischemic cardiomyopathy, 7,8 which may significantly influence the effects
of digoxin. In the Valsartan Heart Failure Trial (Val-HeFT), digoxin use was associated with …

The effect of digoxin on mortality and morbidity in patients with heart failure

Digitalis Investigation Group - New England Journal of Medicine, 1997 - Mass Medical Soc
Digoxin did not reduce overall mortality, but it reduced the rate of … heart failure. These
findings define more precisely the role of digoxin in the management of chronic heart failure. …

Renal function, digoxin therapy, and heart failure outcomes: evidence from the digoxin intervention group trial

MG Shlipak, GL Smith, SS Rathore… - Journal of the …, 2004 - journals.lww.com
… complication for patients with heart failure, but its association … heart failure survival and the
effect of digoxin on heart failure … of 6800 outpatients with systolic heart failure. Renal function …

Digoxin initiation and outcomes in patients with heart failure (HFrEF and HFpEF) and atrial fibrillation

S Singh, H Moore, PE Karasik, PH Lam… - The American journal of …, 2020 - Elsevier
use of digoxin in patients with heart failure and atrial fibrillation, who constitute about a third
of all patients with heart failure. … digoxin initiation and outcomes in patients with heart failure

Digoxin use in contemporary heart failure with reduced ejection fraction: an analysis from the Swedish Heart Failure Registry

CJ Kapelios, LH Lund, L Benson… - European Heart …, 2022 - academic.oup.com
Digoxin is included in some heart failure (HF) guidelines but controversy persists about the
… between clinical characteristics and digoxin use and between digoxin use and mortality/…