… on the applications of systems biology to the study of … biology can be used to inform the
design of new vaccine candidates that are directly engineered to stimulate robust responses in …

… and protective vaccine response. The consistency of these predictive signatures across
several trials, for both CD8+ T cell and antibody responses to the yellow fever vaccine, raises the …

… to vaccine response. We cover how the application of systems biology can advance our
understanding of vaccine … to overcome the lower immunogenicity of vaccines in the elderly. …

… vaccine response remains a challenge. As our knowledge of the immune system deepens, it
becomes clear that vaccine … the biological mechanisms underlying strong humoral and cell-…

… performed by us and others have demonstrated that by understanding crucial genetic
determinants of immune response, we may reveal the basis of vaccine low-response or non-…

… vaccines induce protective immune responses. Here we review the recent advances, challenges,
and potential of systems biological … predictive signatures of vaccine response, as well …

… the use of a systems biology approach to study the immune responses in six individual
immune cell types following vaccination with seasonal trivalent influenza vaccine [29]. That study …

… Antigen presenting cells, such as DCs, play a critical role in priming the adaptive immune
response to establish immune memory and thus vaccine success and are necessary for …

… cell … cell types to the immune response after vaccination, we established a rapid and efficient
method to purify human T and B cells, natural killer (NK) cells, myeloid dendritic cells (mDC)…

… immunity in the host response to vaccine antigens and the potential of systems biology in
providing relevant and novel insights in the mechanisms of action of vaccines to improve their …