Optimizing the clinical use of vancomycin

R Álvarez, LE López Cortés, J Molina… - Antimicrobial agents …, 2016 - Am Soc Microbiol
… (23), a wide range of AUC values from several dosage regimens yielding isometric C min …
of >400 was virtually 100% with different dosage regimens when the trough was 15 to 20 mg/…

Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice

W Zamoner, IRS Prado, AL Balbi… - Clinical and …, 2019 - Wiley Online Library
… them being dependent on the dosage regimen. … dose group (5.8% vs 11.1%, P < 0.001).
After adjustment for age, sex and baseline creatinine, exposure to high dose of vancomycin was …

Vancomycin dosing and monitoring: critical evaluation of the current practice

F Elbarbry - European journal of drug metabolism and …, 2018 - Springer
… the current guidelines of vancomycin dosing and monitoring, … dosing strategies (nomograms)
to improve the efficiency of … equal daily vancomycin doses, the dosing regimen for obese …

Vancomycin dosing in critically ill patients: robust methods for improved continuous-infusion regimens

JA Roberts, FS Taccone, AA Udy… - Antimicrobial agents …, 2011 - Am Soc Microbiol
… optimized vancomycin dosing by continuous infusion in critically ill patients and is the largest
pharmacokinetic study on vancomycin in this setting. Our results show that a loading dose

Performance of a vancomycin dosage regimen developed for obese patients

DC Reynolds, LH Waite, DP Alexander… - American Journal of …, 2012 - academic.oup.com
vancomycin concentrations of >20 μg/mL in approximately 50% of patients. As vancomycin
dosing in … higher-than-desired trough vancomycin concentrations in obese patients and the …

Vancomycin: an update

RPF Cheung, JT DiPiro - Pharmacotherapy: The Journal of …, 1986 - Wiley Online Library
… Because of wide interpatient variability in drug elimination, dosing regimens should be
individualized according to weight and renal function.78~92~94-96 It is suggested that in adult …

Dose regimen for vancomycin not needing serum peak levels?

WH Tan, N Brown, AW Kelsall, RJ McClure - Archives of Disease in …, 2002 - fn.bmj.com
vancomycin dosage regimen used in this study produces acceptable therapeutic serum
vancomycin … assess the suitability of the vancomycin dosage regimen used in our neonatal unit …

Vancomycin loading doses: a systematic review

J Reardon, TTY Lau… - Annals of …, 2015 - journals.sagepub.com
… ≥2 consecutive measurements from vancomycin initiation to 72 hours after last vancomycin
dose … Assessment of the impact of a new loading dose regimen on vancomycin trough levels …

Pharmacokinetic optimisation of vancomycin therapy

WG Leader, MHH Chandler, M Castiglia - Clinical pharmacokinetics, 1995 - Springer
… logical states such as age, body weight and renal function contribute to altered pharmacokinetics
and may alter the design of the dosage regimen. Since no definitive relationship exists …

Assessment of vancomycin dosing and subsequent serum concentrations in pediatric patients

LS Eiland, TM English… - Annals of …, 2011 - journals.sagepub.com
… Our institution was primarily using vancomycin dosing regimens that were recommended
in pediatric references (40-60 mg/kg/day), which resulted in subtherapeutic serum …