Vancomycin dosing: assessment of time to therapeutic concentration and predictive accuracy of pharmacokinetic modeling software

MO Nunn, CE Corallo, C Aubron… - Annals of …, 2011 - journals.sagepub.com
vancomycin dosing and concentrations at our institution and evaluate the predictive accuracy
of … to implementing a pharmacy-based pharmacokinetic service for vancomycin monitoring. …

The dosing and monitoring of vancomycin: what is the best way forward?

PG Drennan, EJ Begg, SJ Gardiner… - International journal of …, 2019 - Elsevier
… This formula for predicting the AUC 24 has been validated in adults and is useful for … 24
can be estimated more accurately, by incorporating a direct measure of vancomycin exposure. …

[HTML][HTML] Towards precision dosing of vancomycin in critically ill patients: an evaluation of the predictive performance of pharmacometric models in ICU patients

CB Cunio, DW Uster, JE Carland, H Buscher… - Clinical Microbiology …, 2021 - Elsevier
… time during the dosing interval [7]. Furthermore, the accuracy of each subsequent concentration
improves, in contrast to linear modelling. The accuracy of dose-prediction software is …

[HTML][HTML] Towards precision dosing of vancomycin: a systematic evaluation of pharmacometric models for Bayesian forecasting

A Broeker, M Nardecchia, KP Klinker… - Clinical Microbiology …, 2019 - Elsevier
accurate visual predictive checks and AUC predictions. Models with less accurate predictive
… models for a priori prediction and Bayesian forecasting of vancomycin in a hospitalized …

A model averaging/selection approach improves the predictive performance of model‐informed precision dosing: vancomycin as a case study

DW Uster, SL Stocker, JE Carland… - Clinical …, 2021 - Wiley Online Library
… In order to evaluate how many candidate models per multimodel approach were required
for accurate predictions, we sequentially excluded the model(s) with the best performance …

Model-informed precision dosing of vancomycin via continuous infusion: A clinical fit-for-purpose evaluation of published PK models

A Heus, DW Uster, V Grootaert, N Vermeulen… - International Journal of …, 2022 - Elsevier
… for a priori prediction and a posteriori forecasting of vancomycin in continuous infusion. …
for predicting overall drug exposure [3]. The most accurate way to guide vancomycin dosing

Prospective validation of a model‐informed precision dosing tool for vancomycin in intensive care patients

R Ter Heine, RJ Keizer, K van Steeg… - British journal of …, 2020 - Wiley Online Library
accurately and precisely predict the vancomycin pharmacokinetics based on a previous
measurement, with a mean prediction … to prospectively evaluate the predictive performance of …

Predictive performance of Bayesian vancomycin monitoring in the critically ill

SW Narayan, Y Thoma, PG Drennan, HY Kim… - Critical care …, 2021 - journals.lww.com
predictive performance needs to be evaluated. This study assesses the predictive performance
of Bayesian models for vancomycin in … accurate, with the exception of vancomycin doses, …

Vancomycin dosing and monitoring: critical evaluation of the current practice

F Elbarbry - European journal of drug metabolism and …, 2018 - Springer
… These studies have proposed several regression equations for the prediction of vancomycin
clearance. Murphy et al., conducted a study to compare the accuracy of seven published …

Optimizing predictive performance of bayesian forecasting for vancomycin concentration in intensive care patients

T Guo, RM van Hest, LB Zwep, LF Roggeveen… - Pharmaceutical …, 2020 - Springer
vancomycin TDM data set collected in ICU patients was used for this analysis, containing
vancomycin concentration-time data, vancomycin dosing … of data and thus the accuracy and the …