Variable numbers of BCR‐ABL transcripts persist in CML patients who achieve complete cytogenetic remission with interferon‐α

A Hochhaus, F Lin, A Reiter, H Skladny… - British journal of …, 1995 - Wiley Online Library
… All 20 patients had evidence of residual disease; the median number of transcripts was 75O/,…
Our findings show that CML has not been eradicated in any patient and that the quantity of …

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML study IV

S Saußele, MP Krauß, R Hehlmann… - Blood, The Journal …, 2015 - ashpublications.org
… -free survival in CML patients treated with nilotinib. A number of different TKIs are now …
The prognostic significance of a candidate variable was assessed with the Wald test. When …

Impact of clinical and morphological variables in classification and regression tree‐based survival (CART) analysis of CML with special emphasis on dynamic features

J Thiele, HM Kvasnicka, TK Zirbes… - European journal of …, 1998 - Wiley Online Library
CML. This lack of information may be due to technical difficulties such as collection and
evaluation of samples in numbers … large number of bone marrow trephines of patients with CML; 2…

Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival

HM Kantarjian, TL Smith, KB McCredie, MJ Keating… - 1985 - ashpublications.org
… of patient pretreatment clinical and laboratory features was investigated in a group of 303
patients … Intensive chemotherapy was given to 97 patients, and 78 underwent an early elective …

Velocity of early BCR-ABL transcript elimination as an optimized predictor of outcome in chronic myeloid leukemia (CML) patients in chronic phase on treatment with …

B Hanfstein, V Shlyakhto, M Lauseker, R Hehlmann… - Leukemia, 2014 - nature.com
… for binary outcome variables. As survival analyses are using time-to-event variables, a traditional
… However, this can be explained by the smaller number of patients investigated (N=301, …

Validation and extension of the EBMT Risk Score for patients with chronic myeloid leukaemia (CML) receiving allogeneic haematopoietic stem cell transplants

JR Passweg, I Walker, KA Sobocinski… - British journal of …, 2004 - Wiley Online Library
… a prognostic score for patients receiving HSCT for CML based on five variables: donor type
[… with Revised Risk Scores with a similar outcome to decrease the number of groups to five. …

Chronic fatigue is the most important factor limiting health-related quality of life of chronic myeloid leukemia patients treated with imatinib

F Efficace, M Baccarani, M Breccia, F Cottone… - Leukemia, 2013 - nature.com
… The number of people living with this disease has doubled since … CML patients are not
known, 7, 8 and in the current analysis we examine a wide range of potentially relevant variables. …

Monitoring patients in complete cytogenetic remission after treatment of CML in chronic phase with imatinib: patterns of residual leukaemia and prognostic factors for …

D Marin, J Kaeda, R Szydlo, S Saunders, A Fleming… - Leukemia, 2005 - nature.com
… CCyR on imatinib is variable: some patients in CCyR show a progressive reduction in the
level of residual disease, some reach a plateau where transcript numbers are relatively stable …

A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction

H Moore, NK Li - Journal of theoretical biology, 2004 - Elsevier
… research on treatments for patients with CML. Our model … CML antigen is present in
proportion to the number of CML cells. … , we first simplify the model by rescaling the variables. …

[HTML][HTML] Factors influencing adherence in CML and ways to improvement: results of a patient-driven survey of 2546 patients in 63 countries

J Geissler, G Sharf, F Bombaci, M Daban… - Journal of Cancer …, 2017 - Springer
… strongly correlated to the number of times the patient has to take the medication daily. Most
… Instead of side effects the variable indicating the management of side effects was used as in …