… It is an important target organ for xenobiotic compounds. For this reason, hepatotoxicity is …
suitable for dedicated mechanistic investigations of liver toxicity. For instance, hepatocytes …

… Amiodarone is highly lipid soluble and tends to accumulate in adipose tissues as well as in
highly perfused organs, eg … risk of hepatotoxicity and/or accumulation, Amiodarone should be …

… study to show a different picture. The lysosomal phospholipoidosis which can be seen by
electron microscopy has been described by many authors [27, 34, 36] in the organs of AMI-…

… and lipid-laden organs such as the liver [17], [… amiodarone hepatotoxicity and does not
appear to play an identifiable role in host susceptibility [35]. Severe amiodarone-induced hepatitis …

… of amiodarone-induced side effects are poorly understood. Accumulation of amiodarone in
tissues and organs … developed amiodarone-induced bullous skin lesions and hepatotoxicity. …

… the liver for several months.24 Hepatic toxicity after amiodarone usually develops more than
a year after the start … The liver is not the only organ affected, and other features include fever, …

… Amiodarone is an antiarrhythmic medication that can adversely effect various organs including
lungs, … , skin discoloration, hepatotoxicity and corneal vortex keratopathy after 8 months of …

… amiodarone can easily accumulate in organs with high-adipose contents; this lipophilic
character is presumed to cause liver injury [20]. Hepatotoxicity due to amiodarone … hepatotoxicity […

… The present study was planned to determine whether the vitamin U exhibits preventive
effects on amiodarone-induced liver toxicity. Male Sprague-Dawley rats were randomly divided …

… reason for hepatotoxicity in our case is Amiodarone as the … case of Amiodarone toxicity
involving three different organs: … receiving maintenance doses of Amiodarone to be frequently …