… function and cardiovascular health, components of a … vasculature, and to review the
controversial role that dietary nitrate, through effects on NO status, may play in cardiovascular health. …

… of vascular health, exerting antiplatelet, antithrombotic, and anti-inflammatory properties
within the vasculature. This short-lived molecule exerts its inhibitory effect on vascular smooth …

… the nitric oxide synthases (NOSs) in both the protection from and initiation of human vascular
… The actions of NO are not limited to the control of cardiac or vascular contractility, but have …

… The diagram also outlines key components of the l-arginine–nitric oxide cascade, which
is catalysed by nitric oxide synthase (NOS). Nitric oxide synthase can be inhibited by …

… A healthy vasculature depends on the integrity of the endothelium with a dynamic autocrine
… -derived nitric oxide (NO) are major critical factors in the pathogenesis of vascular diseases, …

… , inhibits proliferation of vascular smooth muscle cells, and … A dominant mechanism reducing
bioavailability of vascular NO is … between vascular disease and vascular oxidative stress, as …

… Nitric oxide (NO) is synthesized by at least three distinct … important for vascular homeostasis,
keeping the vasculature dilated, … Vascular disease associated with hypercholesterolaemia, …

… vascular homeostasis. One of these factors is the potent vasodilator endothelium-derived
nitric oxide (… The linkage between endothelium-derived NO and cardiovascular health is likely …

Oxidative stress contributes to homeostasis in vascular cells. However, excessive ROS is
pathophysiological and contributes to impaired endothelium-dependent dilation in …

… identified as integral to vascular health. The endothelium produces numerous vasodilator
and vasoconstrictor compounds that regulate vascular tone; the vasodilator, nitric oxide (NO), …