Randomized, placebo-controlled, phase II study of veliparib in combination with carboplatin and paclitaxel for advanced/metastatic non–small cell lung cancer
SS Ramalingam, N Blais, J Mazieres, M Reck… - Clinical Cancer …, 2017 - AACR
… that veliparib … phase III trial of veliparib is underway comparing carboplatin and
paclitaxel given in combination with placebo versus veliparib in patients with advanced-stage …
paclitaxel given in combination with placebo versus veliparib in patients with advanced-stage …
A phase 2 randomised study of veliparib plus FOLFIRI±bevacizumab versus placebo plus FOLFIRI±bevacizumab in metastatic colorectal cancer
V Gorbunova, JT Beck, RD Hofheinz… - British journal of …, 2019 - nature.com
… nor in our phase I study 23 , and the benefit of addition of veliparib to cytotoxic chemotherapy
has thus far mainly been shown in preclinical models. The effect of veliparib on the repair …
has thus far mainly been shown in preclinical models. The effect of veliparib on the repair …
A multi-center, randomized, double-blind phase II study comparing temozolomide (TMZ) plus either veliparib (ABT-888), a PARP inhibitor, or placebo as 2nd or 3rd …
MC Pietanza, LM Krug, SN Waqar, A Dowlati, CL Hann… - 2016 - ascopubs.org
… veliparib, an oral PARP-1/2 inhibitor, and TMZ result in synergistic tumor growth delay or
regression. We hypothesized that adding veliparib … or 2 prior regimens were randomized 1:1 to …
regression. We hypothesized that adding veliparib … or 2 prior regimens were randomized 1:1 to …
A Randomized Phase II Study of Veliparib with Temozolomide Or Carboplatin/Paclitaxel Versus Placebo with Carboplatin/Paclitaxel in Brca1/2 Metastatic Breast …
… In another Phase I study, veliparib was active in patients with … A dose-escalation Phase I
study of veliparib bid on days 1–7 … of veliparib as 40 mg bid A Phase II trial with veliparib and …
study of veliparib bid on days 1–7 … of veliparib as 40 mg bid A Phase II trial with veliparib and …
[HTML][HTML] Randomized phase II trial of cisplatin and etoposide in combination with veliparib or placebo for extensive-stage small-cell lung cancer: ECOG-ACRIN 2511 …
… in relapsed SCLC in a phase I trial. We showed the combination of veliparib with platinum
doublet of cisplatin and etoposide (CE) to be safe and tolerable in a phase I trial. The current …
doublet of cisplatin and etoposide (CE) to be safe and tolerable in a phase I trial. The current …
Results of a phase II randomized trial of cisplatin +/- veliparib in metastatic triple-negative breast cancer (TNBC) and/or germline BRCA-associated breast cancer …
P Sharma, E Rodler, WE Barlow, J Gralow… - 2020 - ascopubs.org
… S1416 compared the efficacy of cisplatin plus PARPi veliparib (Vel) or placebo (P) in 3 groups
of MBC: gBRCA+; BRCA-like; and non-BRCA-like. Methods: Patients (pts) with metastatic …
of MBC: gBRCA+; BRCA-like; and non-BRCA-like. Methods: Patients (pts) with metastatic …
Veliparib in combination with carboplatin and etoposide in patients with treatment-naïve extensive-stage small cell lung cancer: a phase 2 randomized study
… Here, we report results from the Phase 2 part of the study that evaluated veliparib or
placebo in combination with carboplatin and etoposide followed by veliparib or placebo …
placebo in combination with carboplatin and etoposide followed by veliparib or placebo …
Effect of veliparib (ABT-888) on cardiac repolarization in patients with advanced solid tumors: a randomized, placebo-controlled crossover study
W Munasinghe, S Stodtmann, A Tolcher… - Cancer Chemotherapy …, 2016 - Springer
… with either placebo, veliparib 200 mg, or veliparib 400 mg. The … QTcF between the veliparib
400 mg dose and placebo (∆∆… ∆∆QTcF between veliparib 400 mg and placebo was below the …
400 mg dose and placebo (∆∆… ∆∆QTcF between veliparib 400 mg and placebo was below the …
… with veliparib or placebo in metastatic triple-negative breast cancer and BRCA mutation-associated breast cancer (S1416): a randomised, double-blind, placebo …
E Rodler, P Sharma, WE Barlow, JR Gralow… - The Lancet …, 2023 - thelancet.com
… /m 2 , day 1) combined with either veliparib or matching placebo (300 mg orally twice a day,
… who received at least one dose of veliparib or placebo. The study is ongoing and registered …
… who received at least one dose of veliparib or placebo. The study is ongoing and registered …
A phase I/II study of veliparib (ABT-888) in combination with 5-fluorouracil and oxaliplatin in patients with metastatic pancreatic cancer
… recently reported randomized phase II trial of gemcitabine + cisplatin ± veliparib in patients
… study, and would address an important concern (the placebo control arm) of the POLO trial. …
… study, and would address an important concern (the placebo control arm) of the POLO trial. …
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