The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI

YS Tzeng, K Lutchen, M Albert - Journal of applied …, 2009 - journals.physiology.org
… comments on their homogeneity/heterogeneity have remained … with HP 3 He MRI to
quantitatively map ventilation (10), while … ventilation and its heterogeneity using HP 3 He MRI in a …

Linking Ventilation Heterogeneity Quantified via Hyperpolarized 3He MRI to Dynamic Lung Mechanics and Airway Hyperresponsiveness

JK Lui, H Parameswaran, MS Albert, KR Lutchen - PLoS One, 2015 - journals.plos.org
hyperpolarized helium-3 MRI (HP 3 He-MRI) have introduced the ability to render and quantify
ventilation … The goal of this study was to establish how ventilation heterogeneity relates to …

Combined measurement of pulmonary inert gas washout and regional ventilation heterogeneity by MR of a single dose of hyperpolarized 3He

MH Deppe, J Parra‐Robles, S Ajraoui… - Magnetic Resonance …, 2011 - Wiley Online Library
… with 3 He MRI for insight into ventilation heterogeneity. Washout of 3 He is tracked via the
global FID signal of the hyperpolarized gas in the lungs. Complete 3D sets of static ventilation

Comparison of quantitative multiple-breath specific ventilation imaging using colocalized 2D oxygen-enhanced MRI and hyperpolarized 3He MRI

TJ Arai, FC Horn, RC Sá, MR Rao… - Journal of applied …, 2018 - journals.physiology.org
ventilation. The scanning procedure and postprocessing allow us to estimate the regional
distribution of hyperpolarized 3 … methods in terms of quantifying ventilation heterogeneity (32). …

Quantification of regional fractional ventilation in human subjects by measurement of hyperpolarized 3He washout with 2D and 3D MRI

FC Horn, MH Deppe, H Marshall… - Journal of applied …, 2014 - journals.physiology.org
… the term ventilation heterogeneity (VH) is used to describe reduced gas mixing efficiency
due to narrowing or blockage of the conducting and small (<2 mm diameter) airways, causing …

Using hyperpolarized 129Xe MRI to quantify the pulmonary ventilation distribution

M He, B Driehuys, LG Que, YCT Huang - Academic radiology, 2016 - Elsevier
… 129 Xe MRI scans such that the underlying ventilation distribution and its heterogeneity can
be … Quantitative 129 Xe MRI also revealed altered ventilation heterogeneity in response to …

Ventilation‐based segmentation of the lungs using hyperpolarized 3He MRI

NJ Tustison, BB Avants, L Flors, TA Altes… - … magnetic resonance …, 2011 - Wiley Online Library
… information about the homogeneity of ventilation within the … ventilation. We present an
automated algorithmic pipeline for ventilation-based partitioning of the lungs in hyperpolarized 3 …

Hyperpolarized 3He magnetic resonance imaging ventilation defects in asthma: relationship to airway mechanics

D Leary, S Svenningsen, F Guo… - Physiological …, 2016 - Wiley Online Library
… is thought to reflect ventilation heterogeneity. We acquired MRI ventilation defect maps, forced
… airway model to explore the relationship of ventilation defect percent (VDP) with simulated …

Regional heterogeneity of lobar ventilation in asthma using hyperpolarized helium-3 MRI

W Zha, SJ Kruger, RV Cadman, DG Mummy… - Academic radiology, 2018 - Elsevier
… patterns of ventilation heterogeneity in asthma. In a large asthma cohort, the ventilation
distribution … ventilation distribution in asthma with HP gas MRI reveals severity-related regional …

Ventilation heterogeneity imaged by multibreath wash‐ins of hyperpolarized 3He and 129Xe in healthy rabbits

H Hamedani, S Kadlecek, K Ruppert… - The Journal of …, 2021 - Wiley Online Library
magnetic resonance imaging of signal build-up resulting from multiple wash-ins of a
hyperpolarized (… Here, we used normoxic HP 3 He and 129 Xe mixtures to study regional …