Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation

X Zhou, C Li, W Xu, J Chen - PloS one, 2012 - journals.plos.org
… myocardial apoptosis is strongly associated with unfavorable left ventricular remodeling and
… In the present study, cardiomyocyte apoptotic rate was determined by flow cytometry with …

Morphological aspects of apoptosis in heart diseases

G Takemura, H Fujiwara - Journal of cellular and molecular …, 2006 - Wiley Online Library
… of cardiomyocyte apoptosis during myocardial infarction and its relevance to myocardial
remodeling … increased afterload, and cardiac remodeling are possible triggers for cardiomyocyte

G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes

M Harada, Y Qin, H Takano, T Minamino, Y Zou… - Nature medicine, 2005 - nature.com
… Our in vitro results suggest that the protective effects of G-CSF on cardiac remodeling after
myocardial infarction can be attributed in part to reduction of cardiomyocyte apoptosis. To …

“How do cardiomyocytes die?” apoptosis and autophagic cell death in cardiac myocytes

S Kunapuli, S Rosanio, ER Schwarz - Journal of cardiac failure, 2006 - Elsevier
… In addition, the epiphenomenon associated with myocardial infarction and early ventricular
remodeling are potent inducers of apoptosis. These include myocardial stretch, myocardial …

[HTML][HTML] MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis

Y Qin, Y Yu, H Dong, X Bian, X Guo… - International journal of …, 2012 - ncbi.nlm.nih.gov
… In the present study, cardiomyocyte apoptosis rate decreased and myocardial infarction size
reduced in the miR-21 group compared with the control group at 1 week after myocardial I/R …

Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling

H Yin, J Chao, M Bader, L Chao - Peptides, 2007 - Elsevier
… the effects of B1R and B2R agonists on cardiac function, cardiomyocyte apoptosis and LV …
not DBK, reduced apoptotic cardiomyocyte and improved cardiac function and LV remodeling, …

STRESS signaling pathways that modulate cardiac myocyte apoptosis

CP Baines, JD Molkentin - Journal of molecular and cellular cardiology, 2005 - Elsevier
… alters cardiac gene expression that in turn facilitates cellular and whole organ remodeling. …
of both adaptive and maladaptive cardiac remodeling associated with many of the pathology-…

Mechanisms of remodelling a question of life (stem cell production) and death (myocyte apoptosis)

R Ferrari, C Ceconi, G Campo, E Cangiano… - Circulation …, 2009 - jstage.jst.go.jp
… We describe a different approach to the pathogenesis of cardiac remodeling, which … It
follows that inhibition of cardiac myocyte apoptosis is a valid target for the development of …

Cardiomyocyte-Specific Deletion of Gsk3α Mitigates Post–Myocardial Infarction Remodeling, Contractile Dysfunction, and Heart Failure

F Ahmad, H Lal, J Zhou, RJ Vagnozzi, JE Yu… - Journal of the American …, 2014 - jacc.org
ventricular remodeling. We used the Tam-inducible Mer-Cre-Mer system to delete Gsk3α
specifically in cardiomyocytes… is a potent promoter of cardiomyocyte death and apoptosis in the …

Myocyte apoptosis in heart failure

VPM van Empel, ATA Bertrand, L Hofstra… - Cardiovascular …, 2005 - academic.oup.com
… Human heart failure is preceded by a process termed cardiac remodeling in which heart …
cell death of cardiac muscle cells. Cardiomyocyte apoptosis has been documented as a pivotal …