… PI3K/Akt/mTOR pathway is important in regulating the production of MMPs by chondrocytes.
Therefore, selective inhibition of the pathway … that dual inhibition of PI3K and mTOR may be …

… of our study is that vertical inhibition of both PI3K/Akt and mTOR pathway leads to significant
… of mTOR signaling in the dermal fibroblast from SSc patients by detecting p-mTOR and its …

… agents, mTOR inhibitors have had … vertical inhibition of mTOR and Akt in breast cancer cell
lines and xenografts. We assessed the effects of mTOR inhibitor rapamycin and Akt inhibitor …

… In summary, our data indicates that combination of inhibitors targeting IGFR and the PI3K/Akt/mTOR
pathway can improve treatment efficacy for HCC in vitro and in a xenograft mouse …

… vertical inhibition of the PI3K/AKT/mTOR signaling pathway by the PI3K/mTORC1/mTOR2
triple inhibitor PI-103 alone and in combination with the mTORC1 inhibitor rapamycin results …

… We show that all three inhibitor combinations synergistically inhibit proliferation of the three
… observed after vertical inhibition of AKT and mTORC1/2. We demonstrate that AKT kinase …

… the pathway in oncogenesis and the rationale for inhibiting its … involving horizontal and
vertical blockade of the pathway, as … with targeting the PI3K–AKT–mTOR pathway, and predict …

… , vertical inhibition of the PI3K/AKT/mTOR pathway or horizontal inhibition of PI3K/AKT/mTOR …
clinical development of dual inhibitors of PI3K and mTOR as well as the mTOR-selective …

… This observation indicates that vertical inhibition at different levels of the PI3K/Akt/mTOR …
documented the superior efficacy of vertical targeting of the PI3K/Akt/mTOR pathway in T-ALL …

… of its targeted inhibition. In this article we review the data surrounding PI3K/Akt/mTOR inhibition
in … inhibitor resistance [84, 95]—vertical blockade may prevent the shunting of upstream …