… vesicle transport pathway that is required for bone resorption. Attesting to the importance of
this trafficking … to significant impairments in osteoclastic bone resorption in vitro and in vivo. …

… transport to impaired bone resorption, this remains a reasonable hypothesis. While much is
known about the mechanisms by which osteoclasts degrade bone… round of vesicle transport. …

… of vesicular trafficking in bone resorbing osteoclasts and how non-resorbing osteoclasts
create several new plasma membrane domains that are hallmarks of actively resorbing cells. …

… Vesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such
as … system in both bone formation by osteoblasts and bone resorption by osteoclasts. This …

… develops into the RB, the site where bone resorption actually takes place. This is a highly …
vectorial vesicular transport, which also serves to deliver the proteins involved in the resorption …

… transport vesicles fuse with the ruffled border membrane and release the enzymes upon
reaching the boneresorbing … related to functions other than bone resorption per se, recent data …

… bone matrix proteins in CatK containing vesicles. In summary, ODN treatment inhibits bone
resorption by blocking degradation of demineralized collagen in the resorption lacunae, and …

… Briefly, proton transport by osteoclast-derived vesicles is more sensitive to inhibition by
vanadate, nitrate and Tiludronate than similar preparations derived from the kidney in the same …

… Osteoclasts are bone-resorbing cells that maintain bone homeostasis. Polarized vesicular
trafficking … In osteoclasts, the major vesicular trafficking pathways include those related to bone …

… off a compartment beneath the cell where bone degradation occurs (the resorption lacuna).Citation9
Subsequently, polarized vesicular trafficking pathways result in the development of …