Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption
… vesicle transport pathway that is required for bone resorption. Attesting to the importance of
this trafficking … to significant impairments in osteoclastic bone resorption in vitro and in vivo. …
this trafficking … to significant impairments in osteoclastic bone resorption in vitro and in vivo. …
Molecular mechanisms of bone resorption
SL Teitelbaum, Y Abu‐Amer… - Journal of cellular …, 1995 - Wiley Online Library
… transport to impaired bone resorption, this remains a reasonable hypothesis. While much is
known about the mechanisms by which osteoclasts degrade bone… round of vesicle transport. …
known about the mechanisms by which osteoclasts degrade bone… round of vesicle transport. …
Intracellular membrane trafficking in bone resorbing osteoclasts
M Mulari, J Vääräniemi… - Microscopy research and …, 2003 - Wiley Online Library
… of vesicular trafficking in bone resorbing osteoclasts and how non-resorbing osteoclasts
create several new plasma membrane domains that are hallmarks of actively resorbing cells. …
create several new plasma membrane domains that are hallmarks of actively resorbing cells. …
[HTML][HTML] Role of vesicular trafficking in skeletal dynamics
G Stenbeck, FP Coxon - Current opinion in pharmacology, 2014 - Elsevier
… Vesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such
as … system in both bone formation by osteoblasts and bone resorption by osteoclasts. This …
as … system in both bone formation by osteoblasts and bone resorption by osteoclasts. This …
Vesicular trafficking in osteoclasts
FP Coxon, A Taylor - Seminars in cell & developmental biology, 2008 - Elsevier
… develops into the RB, the site where bone resorption actually takes place. This is a highly …
vectorial vesicular transport, which also serves to deliver the proteins involved in the resorption …
vectorial vesicular transport, which also serves to deliver the proteins involved in the resorption …
Molecular mechanisms of bone resorption by the osteoclast
R Baron - The Anatomical Record, 1989 - Wiley Online Library
… transport vesicles fuse with the ruffled border membrane and release the enzymes upon
reaching the boneresorbing … related to functions other than bone resorption per se, recent data …
reaching the boneresorbing … related to functions other than bone resorption per se, recent data …
The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking
P Leung, M Pickarski, Y Zhuo, PJ Masarachia… - Bone, 2011 - Elsevier
… bone matrix proteins in CatK containing vesicles. In summary, ODN treatment inhibits bone
resorption by blocking degradation of demineralized collagen in the resorption lacunae, and …
resorption by blocking degradation of demineralized collagen in the resorption lacunae, and …
Molecular mechanisms of bone resorption An update
R Baron - Acta Orthopaedica Scandinavica, 1995 - Taylor & Francis
… Briefly, proton transport by osteoclast-derived vesicles is more sensitive to inhibition by
vanadate, nitrate and Tiludronate than similar preparations derived from the kidney in the same …
vanadate, nitrate and Tiludronate than similar preparations derived from the kidney in the same …
[HTML][HTML] Rab GTPases in osteoclastic bone resorption and autophagy
… Osteoclasts are bone-resorbing cells that maintain bone homeostasis. Polarized vesicular
trafficking … In osteoclasts, the major vesicular trafficking pathways include those related to bone …
trafficking … In osteoclasts, the major vesicular trafficking pathways include those related to bone …
The regulation of osteoclast function and bone resorption by small GTPases
C Itzstein, FP Coxon, MJ Rogers - Small GTPases, 2011 - Taylor & Francis
… off a compartment beneath the cell where bone degradation occurs (the resorption lacuna).Citation9
Subsequently, polarized vesicular trafficking pathways result in the development of …
Subsequently, polarized vesicular trafficking pathways result in the development of …
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